肺炎患者入院后首剂抗生素上药时间与抗生素持续应用敏感性的关系

The Relationship between the First Dose of Antibiotics and the Sensitivity of Antibiotics to Continuous Use in Patients with Pneumonia after Admission

目的:探讨肺炎患者入院后首剂抗生素上药时间与抗生素持续应用敏感性的关系。方法:选择2016年12月-2018年10月本院收治的肺炎患者120例,根据首剂抗生素上药时间分为<1 h组、1~4 h组和>4 h组,每组40例。所有患者均给予抗生素治疗。比较三组患者的治疗效果、预后情况、抗生素敏感性,以及治疗前后CURB-65、PSI评分。结果:<1 h组患者的治疗总有效率明显高于1~4 h组和>4 h组,1~4 h组患者的治疗总有效率明显高于>4 h组,差异均有统计学意义(P<0.05)。<1 h组患者的抗生素使用时间、住院时间、病死率均明显低于1~4 h组和>4 h组,<1 h组患者的病灶吸收率明显高于1~4 h组和>4 h组,1~4 h组的抗生素使用时间、住院时间、病死率均明显低于>4 h组,1~4 h组的病灶吸收率明显高于>4 h组,差异均有统计学意义(P<0.05)。<1 h组患者治疗后的CURB-65、PSI评分均明显低于1~4 h组和>4 h组,1~4 h组患者治疗后的CURB-65、PSI评分均明显低于>4 h组,差异均有统计学意义(P<0.05)。三组的药物敏感性基本相同,差异无统计学意义(P>0.05)。结论:及时应用首剂抗生素能够有效治疗肺炎患者,缩短肺炎患者的抗生素使用时间和住院时间,且可有效改善患者的预后,值得临床做进一步推广。

Objective:To discuss the relationship between the first dose of antibiotics and the sensitivity of antibiotics to continuous use in patients with pneumonia after admission.Method:A total of 120 patients with pneumonia were selected from December 2016 to October 2018 in our hospital.According to the time of first dose of antibiotics,they were divided into<1 h group,1-4 h group and>4 h group,40 cases in each group.All patients were treated with antibiotics.Patients among the three groups were compared for their therapeutic efficacy,prognosis,antibiotic sensitivity,and CURB-65 and PSI scores before and after treatment.Result:The therapeutic effect of<1 h group was significantly higher than those of<1-4 h group and<4 h group,the therapeutic effect of<1-4 h group was significantly higher than that of<4 h group,the differences were statistically significant(P<0.05).The time of antibiotic use,hospitalization time and mortality in<1 h group were significantly lower than those in 1-4 h group and>4 h group,the absorption rate of lesions in<1 h group was significantly higher than those in 1-4 h group and>4 h group,the time of antibiotic use,hospitalization time and mortality in 1-4 h group were significantly lower than those in>4 hour group,and the absorption rate of lesions in 1-4 h group was significantly higher than that in>4 h group,the differences were statistically significant(P<0.05).The CRUB-65 and PSI scores in the<1 h group were significantly lower than those in the 1-4 h group and the>4 h group,and the CRUB-65 and PSI scores in the 1-4 h group were significantly lower than those in the<4 h group,the differences were statistically significant(P<0.05).The drug sensitivity of the three groups was basically the same,with no significant difference(P>0.05).Conclusion:Timely application of the first dose of antibiotics can effectively treat pneumonia patients,shorten antibiotic use time and hospitalization time in pneumonia patient,it can effectively improve the prognosis of patients,it’s worth for further clinical promotion.