LncRNA-PRNCR1多态性与肠癌易感性及预后的关系

The Relationship between Polymorphism of LncRNA-PRNCR1 and Susceptibility and Prognosis of Intestinal Cancer

目的:研究LncRNA-PRNCR1多态性与肠癌易感性及预后的关系。方法:分别比较对照组以及观察组LncRNA-PRNCR1多态性之间的差异,分析LncRNA-PRNCR1多态性与结直肠癌患者的易感性以及预后的相关性。结果:两组rs16901946中的基因型比较,差异有统计学意义(P<0.05),与rs16901946中的AG、GG、AG/GG基因型位点相比,AA位点的肠癌发病率较高(P<0.05)。在≥58岁患者中,rs16901946中的AA基因型与肠癌的易感性相关,其OR值为1.801,在<58岁患者中,其OR值为0.960。同时,在加性模型中显示,≥58岁患者中,每增加一个等位基因A,患者的结直肠癌风险增加33.3%;女性患者中,每增加一个等位基因A,患者直肠癌风险增加11.3%,差异均有统计学意义(P<0.05)。通过对不同基因型结肠癌患者的总体生存情况比较,患者的生存时间之间的差异有统计学意义(P<0.05)。结论:患者LncRNA-PRNCR1中的rs16901946基因突变与患者的结直肠癌的进展密切相关,未来可通过对患者的多基因量化分析,对肿瘤细胞的激活进行预测。

Objective:To study the relationship between polymorphism of LncRNA-PRNCR1 and susceptibility and prognosis of intestinal cancer.Method:The differences of LncRNA-PRNCR1 polymorphism between control group and observation group were compared,and the correlation between LncRNA-PRNCR1 polymorphism and susceptibility and prognosis of patients with colorectal cancer was analyzed.Result:The difference of rs16901946 genotype between the two groups was statistically significant(P<0.05),compared with the AG,GG and Ag/GG genotypes in rs16901946,the incidence of colorectal cancer at AA locus was higher(P<0.05).In patients≥58 years old,the AA genotype in rs16901946 was associated with the susceptibility to colorectal cancer,and OR value was 1.801;in patients<58 years old,the OR value was 0.960.At the same time,in the additive model,the risk of colorectal cancer increased by 33.3%for every allele A increased in patients≥58 years old;for every allele A increased in female patients,the risk of rectal cancer increased by 11.3%,the differences were statistically significant(P<0.05).The difference of survival time of patients with different genotypes of colon cancer was statistically significant(P<0.05).Conclusion:The rs16901946 gene mutation in lncRNA-PRNCR1 is closely related to the progress of colorectal cancer in patients.In the future,the activation of tumor cells can be predicted by quantitative analysis of multiple genes in patients.