扶正消积汤联合卡培他滨、奥沙利铂治疗晚期结肠癌临床观察

Clinical Study of Fuzheng Xiaoji Decoction Combined with Capecitabine and Oxaliplatin in the Treatment of Advanced Colon Cancer

目的:探讨扶正消积汤联合卡培他滨、奥沙利铂对晚期结肠癌患者血清癌胚抗原(CEA)、T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)及生活质量(EORTC QLQ-C30)的影响。方法:选取84例晚期结肠癌患者,根据治疗方案不同分为对照组(n=42)和观察组(n=42)。对照组采用卡培他滨^+奥沙利铂治疗,观察组于对照组基础上联合扶正消积汤治疗,2组均持续治疗4个化疗周期。比较2组治疗效果、不良反应发生情况、治疗前后血清CEA、CD3^+、CD4^+、CD4^+/CD8^+水平、EORTC QLQ-C30评分及癌因性疲乏程度(PFS)。结果:观察组疾病控制率(85.71%)高于对照组(64.29%)(P<0.05);疗程结束后,观察组血清CEA水平低于对照组,血清CD3^+、CD4^+、CD4^+/CD8^+水平均高于对照组(P<0.05);观察组EORTC QLQ-C30评分(65.29±9.33)分高于对照组(59.33±8.72)分,PFS评分(5.39±1.74)分低于对照组(6.51±1.92)分(P<0.05);观察组骨髓抑制、白细胞减少、肝功能降低、恶心呕吐发生率(4.76%、28.57%、7.14%、30.95%)均低于对照组(23.91%、54.76%、26.19%、54.76%)(P<0.05)。结论:扶正消积汤联合卡培他滨、奥沙利铂治疗晚期结肠癌患者,疗效显著,安全性高,可进一步改善机体免疫功能,减轻癌因性疲乏程度,提高患者生活质量。

Objective:To study the effect of Fuzheng Xiaoji Decoction combined with capecitabine and oxaliplatin on serum carcinoembryonic antigen(CEA),T lymphocyte subsets(CD3^+,CD4^+,CD4^+/CD8^+)and quality of life in patients with advanced colon cancer(The impact of EORTC QLQ-C30).Methods:84 patients with advanced colon cancer were enrolled in our hospital.They were divided into control group(n=42)and study group(n=42)according to different treatment options.The control group was treated with capecitabine^+oxaliplatin.The study group was treated with Fuzheng Xiaoji Decoction on the basis of the control group.The two groups continued treatment for 4 cycles of chemotherapy.The therapeutic effects,adverse reactions,serum CEA,CD3^+,CD4^+,CD4^+/CD8^+levels,EORTC QLQ-C30 scores,and cancer-induced fatigue(PFS)were compared between the two groups.Results:The disease control rate of the study group(85.71%)was higher than that of the control group(64.29%)(P<0.05).After the treatment,the serum CEA level of the study group was lower than that of the control group,and the serum CD3^+,CD4^+,CD4^+/CD8^+levels were higher than the control group(P<0.05);after the treatment,the EORTC QLQ-C30 score(65.29±9.33)in the study group was higher than that in the control group(59.33±8.72),and the PFS score(5.39±1.74)was lower than the control group(6.51±1.92)points(P<0.05);the study group had lower myelosuppression,leukopenia,decreased liver function,nausea and vomiting(4.76%,28.57%,7.14%,30.95%)than the control group(23.91%,54.76%,26.19%,54.76%)(P<0.05).Conclusion:Fuzheng Xiaoji Decoction combined with capecitabine and oxaliplatin is effective and safe in the tleament of pafients with advanced colon cancer.It can further reduce serum CEA levels,improve immune function,reduce the incidence of adverse reactions and cancer-related fatigue,and improve patients’quality of life.