密质骨弥散性微损伤非骨重建自修复

Self-repair of diffuse microdamage in cortical bone

弥散性微损伤是骨疲劳引发的主要骨微损伤之一。骨损伤修复普遍认为完全通过骨重建过程完成。研究发现与线性裂痕不同,弥散性微损伤的骨细胞未凋亡,损伤区在"无骨重建过程"下进行了直接修复。基于此新发现,本文对弥散性基质微损伤的特殊自修复相关机制研究进行综述,旨在为骨微损伤修复研究提供一个新视角,并为临床治疗骨组织疾病提供新思路。

Diffuse microdamage is one of a range of matrix damage types that results from fatigue in bone.Bone remodeling has been widely held to be the mechanism by which bone microdamage is repaired.However,recent studies showed that unlike linear microcracks,diffuse microdamages did not activate the remodeling process.Interestingly,diffuse microdamages mechanically and structurally repaired in cortical bone in vivo over time.In this review,we discussed the potential mechanism of self-repair in diffuse microdamage,gave a fresh perspective on the mechanisms of bone repair at the submicron level,and provided a new thought for bone disease treatment.