肌少症的动物模型

Animal models of sarcopenia

肌少症是一种增龄性疾病,年龄越大其患病风险越高。随着对肌少症的认识逐渐加深,本疾病已成为一种主要的老年性临床疾病,也是健康老龄化的关键挑战。肌少症的标志性症状是肌肉质量和力量的减少或丧失,而不损失整体体重。与健康个体相比,肌少症患者伴随其他疾病发病时,其临床预后可能更差,死亡率更高。因此,本病动物模型的开发和使用就显得十分重要。本文以国内外对于肌少症动物模型中衰老模型、衰老+高脂饮食模型、加速衰老模型、后肢卸载模型及基因敲除等动物模型以及其评判指标的研究现状做一综述。

Sarcopenia is an age-related disease,the higher the age,the greater risk of illness.With the deepening of the understanding of sarcopenia,this disease has become a major clinical senile disease and it is a key challenge for healthy aging.The hallmark symptom of sarcopenia is the reduction or loss of muscle mass and strength without losing overall weight.Compared with healthy individuals,patients with sarcopenia may have worse clinical outcomes and higher mortality.Therefore,it is important to develop and use relevant animal models to further carry out the study of sarcopenia.In this article,we briefly summarize the research status of animal models of sarcopenia such as aging model,aging + high-fat diet model,accelerated aging model,hind limb unloading model and gene knockout model and its evaluation indicators.