厚朴乙醇提取物固体分散体的制备

Preparation of solid dispersions of Magnoliae officinalis Cortex ethanol extract

目的制备厚朴乙醇提取物固体分散体。方法药材经70%乙醇提取后,溶剂法制成固体分散体。在单因素试验基础上,以载体(PEG6000⁃F68)比、药载比、搅拌时间为影响因素,厚朴酚、和厚朴酚总溶出度为评价指标,Box⁃Behnken响应面法优化制备工艺。然后,通过扫描电镜(SEM)、差示量热扫描分析(DSC)、傅里叶变换红外光谱(FT⁃IR)进行体外表征。结果最佳条件为载体比0.9∶1,药载比1∶5.4,搅拌时间115 min,60 min内总溶出度为97.12%。所得固体分散体以无定型状态存在,制备过程中发生了化学反应。结论固体分散体可明显改善厚朴乙醇提取物中有效成分的溶解性。

AIM To prepare the solid dispersions of Magnoliae officinalis Cortex ethanol extract.METHODS The medicinal material was extracted with 70%ethanol and then prepared into solid dispersions by solvent method.With carrier(PEG6000⁃F68)ratio,drug⁃carrier ratio and stirring time as influencing factors,the total dissolution rate of magnolol and honokiol as an evaluation index,the preparation process was optimized by Box⁃Behnken response surface method on the basis of single factor test.Subsequently,the in vitro characterization was performed by scanning electron microscopy(SEM),differential scanning calorimetry(DSC)and Fourier trans⁃form infrared spectroscopy(FT⁃IR).RESULTS The optimal conditions were determined to be 0.9∶1 for carrier ratio,1∶5.4 for drug⁃carrier ratio,and 115 min for stirring time,the total dissolution rate within 60 min was 97.12%.The obtained solid dispersions existed in an amorphous state,and chemical reaction occurred during the preparation.CONCLUSION Solid dispersions can obviously improve the solubilities of effective components in Magnoliae officinalis Cortex ethanol extract.