风湿性多肌痛患者红细胞沉降率和炎性因子表达情况及与其病情严重程度的相关性分析

Erythrocyte Sedimentation Rate and Expressions of Inflammatory Factors in Patients with Polymyalgia Rheumatica and Their Correlations with Severity of Pathogenetic Condition

目的分析风湿性多肌痛(PMR)患者红细胞沉降率(ESR)和炎性因子[C反应蛋白(CRP)、白介素-6(IL-6)]表达情况及与其病情严重程度的相关性。方法选取我院2016年12月-2018年12月收治的PMR患者66例为观察组,选取同时期类风湿关节炎(RA)患者36例为对照组。回顾性分析2组患者的临床资料,检测其ESR、CRP、IL-6表达水平,分析ESR、CRP、IL-6与PMR患者病情的相关性。结果观察组CRP、IL-6、ESR水平显著高于对照组(P<0.05),ESR、CRP、IL-6水平均随PMR-AS评分的增高而上升(P<0.05);年龄、BMI、合并高酯血症、ESR、CRP与IL-6水平升高可加重PMR患者病情(P<0.05);合并高血脂病、ESR值、CRP与IL-6水平是影响PMR病情的独立危险因素(P<0.05)。结论ESR、CRP与IL-6水平是影响PMR患者病情严重程度的重要指标,ESR、CRP、IL-6水平升高可增加PMR病情活动度。

Objective To analyze expressions of erythrocyte sedimentation rate(ESR)and inflammatory factors[C-reactive protein(CRP)and interleukin-6(IL-6)]in patients with polymyalgia rheumatica(PMR)and their correlation with severity of the pathogenetic condition.Methods A total of 66 PMR patients admitted during December 2016 and December 2018 were selected as observation group,and other 36 patients with rheumatoid arthritis(RA)at the same period were selected as control group.Clinical data of the two groups was retrospectively analyzed.and expressions of ESR,CRP and IL-6 were detected in all patients,and correlations of ESR,CRP and IL-6 with pathogenetic conditions of PMR patients were analyzed.Results Levels of ESR,CRP and IL-6 in observation group were significantly higher than those in control group(P<0.05).ESR,CRP and IL-6 levels were increased with increasing PMR activity score(PMR-AS)(P<0.05).Age,body mass index(BMI),combined with hyperlipidemia and increasing ESR,CRP and IL-6 levels could aggravate condition of PMR patients(P<0.05).Combined with hyperlipidemia,ESR value,CRP and IL-6 levels were independent risk factors for PMR(P<0.05).Conclusion Levels of ESR,CRP and IL-6 are important indicators affecting severity of PMR.Activity of PMR can be increased by increasing ESR,CRP and IL-6 levels.