左氧氟沙星序贯疗法治疗社区获得性肺炎的临床疗效

Clinical Efficacy of Levofloxacin Sequential Therapy in the Treatment of Community Acquired Pneumonia

目的:评价左氧氟沙星与阿奇霉素的序贯疗法分别对社区获得性肺炎的治疗效果。方法:选取2014年3月~2018年6月间某院收治的84例社区获得性肺炎患者作为研究对象,按抽签法随机均分为观察组和对照组,各42例。观察组使用左氧氟沙星序贯疗法,对照组使用阿奇霉素序贯疗法,比较两组患者治疗7天后的总有效率、退热时间、咳嗽消失时间、啰音消失时间、治疗时间和T淋巴细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)。结果:治疗后7d观察组总有效率为95.24%,较总有效率为71.43%的对照组高,差异有统计学意义;用药后观察组的症状消退时间和治疗时间分别较对照组短,差异有统计学意义;治疗前两组患者T淋巴细胞亚群比较无统计学意义,治疗结束后T淋巴细胞亚群均有改善,差异有统计学意义,且观察组效果更甚。治疗期间两组均未出现严重不良反应。结论:对于社区获得性肺炎的治疗,左氧氟沙星序贯疗法较阿奇霉素序贯疗法有更高的临床总有效率和更短的住院医治时间。

Objective:To evaluate the effect of sequential therapy of levofloxacin and azithromycin in the treatment of community acquired pneumonia.Methods:84patients with community acquired pneumonia admitted to a hospital from March 2014to June 2018were selected as the research objects.They were randomly divided into observation group and control group,42cases in each group.The observation group was treated with levofloxacin sequential therapy,while the control group was treated with azithromycin sequential therapy.The total effective rate,antipyretic time,cough disappearance time,ralogue disappearance time,treatment time and T lymphocyte subsets(CD4^+,CD8^+,CD4^+/CD8^+)were compared between the two groups after 7days of treatment.Results:The total effective rate was 95.24%in the observation group 7days after treatment,higher than 71.43%in the control group,the difference was statistically significant.The symptoms subsidence time and treatment time in the observation group were shorter than those in the control group,the difference was statistically significant.Before treatment,there was no significant difference in T lymphocyte subsets between the two groups,and after treatment,the T lymphocyte subsets were improved,and the effect in the observation group was even better,the difference was statistically significant.During the treatment period,no serious adverse reactions occurred in both groups.Conclusion:In the treatment of community acquired pneumonia,levofloxacin sequential therapy has higher clinical total effective rate and shorter hospitalization time compared with azithromycin sequential therapy.