摘要
目的建立确证阿昔洛韦化学结构的方法。方法通过紫外光谱,红外光谱,超高分辨质谱,1D/2D核磁共振,热分析及X-射线粉末衍射对阿昔洛韦的结构进行分析。结果通过解析证实了阿昔洛韦的化学结构为9-(2-羟乙氧甲基)鸟嘌呤。结论该方法准确可行,可为阿昔洛韦的结构鉴定提供依据。
Objective To identify the chemical structure of acyclovir.Methods UV,IR,FT-MS,NMR,DSC,TGA,and X-ray powder diffraction were used to analyze the chemical structure of acyclovir.Results The chemical structure of acyclovir was 9-(2-hydroxyethoxymethyl)guanine.Conclusion The method is accurate and practical,and can provide a reference for the structure identification of acyclovir.
作者
王玲
代欢欢
严定策
曾甜甜
梁平
江任之
WANG Ling;DAI Huan-huan;YAN Ding-ce;ZENG Tian-tian;LIANG Ping;JIANG Ren-zhi(Analytical Testing Center,Huazhong University of Science and Technology,Wuhan 430074;Wuhan No.4 Hospital,Wuhan 430033)
出处
《中南药学》
CAS
2019年第12期2044-2048,共5页
Central South Pharmacy
关键词
阿昔洛韦
结构确证
核磁共振
acyclovir
structure identification
nuclear magnetic resonance
