临床药师参与1例泛耐药肺炎克雷伯菌血流感染患者的抗感染治疗

Clinical pharmacists participate in one case of anti-infection therapy of bloodstream infection caused by pandrug-resistant Klebsiella pneumoniae

临床药师通过参与1例泛耐药肺炎克雷伯菌血流感染患者的治疗,根据药物的药物代谢动力学与药物效应动力学(PK/PD)特点,细菌的药敏结果,并通过检索查阅文献,向医师建议在原有治疗基础上联合使用多黏菌素B膀胱冲洗,并增加替加环素剂量,且在降阶梯治疗效果不佳时及时将磷霉素更换为替加环素,医师予以采纳,最终患者的感染得到安全有效的控制,并未发生明显不良反应。

According to the characteristics of pharmacokinetics and pharmacokinetics(PK/PD) of drugs and the pharmacosensitivity results of bacteria, and by searching the literature, the clinical pharmacist advised doctor to use polycolistin B bladder irrigation on the basic of original treatment, increase the dose of tigacycline, and replace fosfomycin with tigacycline in time when the effect of ladder lowering treatment was not good through participating in the treatment of a patient with pandrug-resistant Klebsiella pneumoniae bloodstream infection, these advices was all adopted by doctors, and finally, the patient’s infection was safely and effectively controlled without obvious adverse reactions.