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前列腺癌诊疗中前列腺特异膜抗原分子靶向探针的应用 被引量:2

Application of probes for targeting prostate-specific membrane antigen molecular in diagnosis and treatment of prostate cancer
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摘要 前列腺癌在中老年男性恶性肿瘤死亡原因中居于第2位,相当一部分患者在早期不易被发现,传统影像学检查虽然对前列腺癌的诊断、分期均有较高的价值,但也有一定局限性。随着核医学仪器及分子探针的研发,分子影像在前列腺癌的诊疗过程中发挥着越来越重要的作用,以前列腺特异膜抗原(prostate-specific membrane antigen,PSMA)作为探针的正电子发射计算机断层成像(positron emission tomography and computed tomography,PET/CT)技术得到了越来越多的认可。该文围绕PSMA分子靶向探针应用于前列腺癌PET/CT显像及治疗的最新进展进行综述,旨在为前列腺癌诊疗中PSMA分子靶向探针的应用提供一定的理论基础。 Prostate cancer ranks second among the causes of death of malignant tumors in middle-aged and elderly men. A considerable number of patients are not easily detected in early-stage prostate cancer. Although traditional imaging examinations are of high value in the diagnosis and staging of prostate cancer, they also have certain limitations.With the development of nuclear medicine instruments and molecular probes, molecular imaging is playing an increasingly important role in the diagnosis and treatment of prostate cancer. Positron emission tomography and computed tomography(PET/CT) using prostate-specific membrane antigen(PSMA) as a probe has gained increasing recognition. This article will review the latest progress in the application of PET/CT using probes for targeting PSMA to imaging and treatment of prostate cancer, in order to provide a theoretical basis for the application of probes for targeting PSMA in the diagnosis and treatment of prostate cancer.
作者 许晓宇 李兴昶 吕诗剑 徐玲玲 赖建平 XU Xiaoyu;LI Xingchang;LShijian;XU Lingling;LAI Jianping(Department of Nuclear Medicine,the People's Hospital of Three Gorge University,the First People's Hospital of Yichang,Yichang,Hubei 443000,P.R.China)
出处 《华西医学》 CAS 2020年第1期98-102,共5页 West China Medical Journal
关键词 正电子发射断层成像 计算机断层扫描 前列腺特异膜抗原 前列腺癌 Positron emission tomography Computed tomography Prostate-specific membrane antigen Prostate cancer
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