良性前列腺增生并发前列腺炎患者前列腺液白细胞介素水平与前列腺特异性抗原的相关性研究

Correlation study between benign prostatic fluid interleukin levels and prostate specific antigen in patients with benign prostatic hyperplasia complicated with prostatitis

目的研究良性前列腺增生(BPH)并发前列腺炎患者的前列腺液白细胞介素水平和前列腺特异性抗原(PSA)的相关性。方法回顾本院2014年7月到2018年1月本院收治的115例良性前列腺增生患者的临床资料,分析其并发前列腺炎的情况、前列腺液白细胞介素水平、总PSA(TPSA)和游离PSA(FPSA)及FPSA/TPSA。结果115例BPH患者中有76例并发前列腺炎,其中I级炎症37例、II级炎症25例、III级炎症13例。III级炎症组的炎症范围、炎症程度均显著高于I级、II级炎症组,差异均有统计学意义(P<0.05)。III级炎症组的IL-2、IL-6、IL-8、IL-10均显著高于I级炎症组、II级炎症组,差异均有统计学意义(P<0.01)。III级炎症组的TPSA、FPSA显著高于I级炎症组、II级炎症组,差异均有统计学意义(P<0.01);三组的FPSA/TPSA比较,差异无统计学意义(P>0.05)。经Pearson直线相关法分析,BPH并发前列腺炎患者的前列腺液IL-2与PSA、FPSA均无显著相关性(P>0.05);前列腺液IL-6、IL-8、IL-10与TPSA、FPSA均呈显著正相关(P<0.05)。结论BPH并发前列腺炎是患者PSA升高的危险因素,且患者前列腺液的IL-6、IL-8、IL-10水平与PSA存在良好的相关性,临床可据此进行BPH并发前列腺炎的诊断和治疗,以提高临床疗效。

Objective To study the correlation between benign prostatic fluid interleukin levels and prostate specific antigen(PSA)in patients with benign prostatic hyperplasia(BPH)complicated with prostatitis.Methods The clinical data of 115 patients with BPH treated in our hospital from July 2014 to January 2018 were retrospectively analyzed.The situation of concurrent prostatitis,prostatic fluid interleukin levels,total PSA(TPSA)and free PSA(FPSA)and FPSA/TPSA were analyzed.Results In the 115 BPH patients,76 patients had prostatitis,including 37 cases of grade I inflammation,25 cases of II-grade inflammation,and 13 cases of grade III inflammation.The extent of inflammation and the degree of inflammation in the grade III-grade inflammation group were significantly higher than those in the I-grade and II-grade inflammation groups,and the differences were statistically significant(P<0.05).IL-2,IL-6,IL-8 and IL-10 in the III-grade inflammation group were significantly higher than those in the I-grade inflammation group and the II-grade inflammation group,and the differences were statistically significant(P<0.01).The TPSA and FPSA of the III-grade inflammation group were significantly higher than those of the I-grade inflammation group and the II-grade inflammation group,and the differences were statistically significant(P<0.01).There was no significant difference in FPSA/TPSA between the three groups(P>0.05).According to Pearson linear correlation analysis,there was no significant correlation between prostatic fluid IL-2 and PSA and FPSA in patients with BPH complicated with prostatitis(P>0.05).Prostatic fluid IL-6,IL-8,IL-10 were positively correlated with TPSA and FPSA(P<0.05).Conclusions BPH complicated with prostatitis is a risk factor for elevated PSA in patients,and the levels of IL-6,IL-8,IL-10 in prostatic fluid have a good correlation with PSA.Clinically,the diagnosis and treatment of BPH complicated with prostatitis can be performed according this,and improve clinical efficacy.