血清apo A1、apo B、apo E与特应性皮炎的相关性

Correlation between serum apo A1,apo B,apo E and atopic dermatitis

目的探讨血清载脂蛋白(apo)A1、apo B、apo E水平与特应性皮炎(AD)的相关性。方法选取230例AD患者及100名无过敏性疾病史的体检健康者,检测血清apo A1、apo B、apo E、总免疫球蛋白E(IgE)及过敏原[特异性免疫球蛋白E(sIgE)]水平。采用Logistic回归分析评估各项目及其与AD发病风险的关系。结果AD组和正常对照组女性血清apo A1水平均高于男性(P<0.05)。AD组女性血清apo A1水平高于正常对照组女性(P<0.05)。AD组男性血清apo B水平低于正常对照组男性(P<0.01)。sIgE阳性者男女比例与总IgE>200 kU/L者比较,差异无统计学意义(P>0.05)。以7岁为年龄分组界限,≤7岁组与>7岁组sIgE阳性率和总IgE>200 kU/L比例差异均无统计学意义(P>0.05)。apo A1、apo B与apo E均呈正相关(r值分别为0.190、0.287,P<0.01)。apo A1与apo B无相关性(r=0.030,P>0.05)。apo A1、apo B和apo E均与年龄呈正相关(r值分别为0.191、0.417、0.143,P<0.01)。Logistic回归分析结果显示,apo A1可增加AD的发病风险[比值比(OR)=7.346,95%可信区间(CI)为2.349~22.977],但与总IgE和sIgE无关;apo B校正年龄、性别后与AD发病风险无关,但可增加总IgE>200 kU/L的风险(OR=6.694,95%CI为1.739~25.762)。apo E无论是否校正年龄和性别均与AD发病风险、总IgE和sIgE无关。结论apo A1可能是独立于IgE介导的参与AD发病的危险因子。apo B受年龄、性别等因素的影响较大,与AD发病风险的关系尚不明确。apo E与AD的发病风险无关。

Objective To investigate the relationship between atopic dermatitis and the levels of serum apolipoprotein(apo)A1,apo B and apo E.Methods Totally,230 AD patients and 100 healthy subjects without the history of allergic diseases were enrolled.The levels of apo A1,apo B,apo E,total immunoglobulin E(IgE)and allergen[specific immunoglobulin E(sIgE)]were determined.Logistic regression analysis was used to evaluate the relationship between all the items and AD risk.Results Serum apo A1 levels of females in AD group and healthy control group were higher than those of males(P<0.05).Serum apo A1 level of females in AD group was higher than that in healthy control group(P<0.05).Serum apo B level of males in AD group was lower than that in healthy control group(P<0.01).There was no statistical significance for the ratio of males and females with positive sIgE and total IgE>200 kU/L(P>0.05),and there was no statistical significance between the group≤7 years old and the group>7 years old(P>0.05).Serum apo A1,apo B and apo E were positively correlated(r=0.190 and 0.287,respectively,P<0.01).Serum apo A1 and apo B were not correlated(r=0.030,P>0.05).Serum apo A1,apo B and apo E were positively correlated with age(r=0.191,0.417 and 0.143,respectively,P<0.01).Logistic regression analysis showed that apo A1 could enable AD happening easily[odds ratio(OR)=7.346,95%confidence interval(CI)2.349-22.977],however,total IgE and sIgE had no correlation.After adjusting age and sex,apo B was not correlated with the risk of AD,while it can put total IgE>200 kU/L more in danger(OR=6.694,95%CI 1.739-25.762).Serum apo E always had no correlation with the risk of AD,total IgE and sIgE regardless of age or sex adjustment.Conclusions Serum apo A1 may be a risk factor contributing to the risk of AD,which is independent from IgE mediating.As apo B is influenced by factors,like age and sex,whether it can contribute to the risk of AD is not clear.Serum apo E will not cause the risk of AD.