普洱边疆地区常驻民脑出血患者预后因素相关性研究

Correlation of Prognostic Factors in Patients with Cerebral Hemorrhage in Pu’er Area

目的探讨脑出血预后因素的相关性。方法检测正常体检共56例、脑出血共53例,检测患者ApoE基因多态性,以及各项基线指标,对比各因素对患者预后有无差异性。结果脑出血组的ε2的基因频率为11,占20.8%,ε3的基因频率为30,占56.6%,ε4的基因频率为12,占22.6%;正常体检组的ε2的基因频率为12,占21.4%,ε3的基因频率为30,占53.6%,ε4的基因频率为14,占25%,但各组间的通过卡方检验均无统计学意义。各等位基因以ε3作为比较的基准,通过Logistic回归分析,ε2、ε4与脑出血预后差异无统计学意义。结论在普洱市常驻民中,ApoE各等位基因与脑出血预后无相关,ICH score高低与脑出血预后存在相关性。

Objective To investigate the correlation of prognostic factors of cerebral hemorrhage.Methods ApoE gene polymorphism was detected in 56 cases of normal physical examination and 55 cases of cerebral hemorrhage,The ApoE gene polymorphism and the baseline indicators were detected,and the prognosis of the patients was compared.Results The frequency ofε2 in cerebral hemorrhage group was 11,accounting for 20.8%,ε3 frequency is 30,accounting for 56.6%,ε4 frequency is 24,accounted for 56.6%;the frequency ofε2 in normal group is 12,accounting for 21.4%,ε3 frequency is 30,accounting for 53.6%,ε4 frequency is 14,accounted for 25%,but each group by chi square test showed no statistical significance.The allele of each allele was compared with the standard ofε3.By Logistic regression analysis,there was no statistically significant difference in the prognosis ofε2 andε4 with cerebral hemorrhage.Conclusion In Pu’er city resident,no significant differences between ApoE gene polymorphism and cerebral hemorrhage prognosis from Pu’er.There is a correlation between ICH score and the prognosis of cerebral hemorrhage.