不同严重程度支气管肺炎患儿血清PCT、CRP、IL-1水平变化分析

Analysis of Changes of Serum PCT, CRP and IL-1 Levels in Children Patients with Different Severity of Bronchial Pneumonia

目的分析不同严重程度支气管肺炎患儿血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-1(IL-1)水平的变化。方法选择2017年1月到2019年1月我院收治的76例支气管肺炎患儿,根据入院时病情严重程度分为轻症组(42例)和重症组(34例),另选取同时期本院体检健康的30例儿童为对照组。于入院当日及治疗15d后检测各组血清PCT、CRP、IL-1水平变化。结果轻症组和重症组患儿血清PCT、CRP、IL-1水平均显著高于对照组,且重症组患儿血清PCT、CRP、IL-1水平明显高于轻症组,差异有统计学意义(P<0.05);治疗后两组患儿血清PCT、CRP、IL-1水平均较治疗前显著降低,且轻症组明显低于重症组,差异有统计学意义(P<0.05)。结论在小儿支气管肺炎的发病过程中,PCT、CRP、IL-1均有参与,且与疾病严重程度有关,可指导临床诊断、病情及预后评估。

Objective To analyze the changes of levels of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-1(IL-1)in children patients with different severity of bronchial pneumonia.Methods 76 children patients with bronchial pneumonia admitted to our hospital from January 2017 to January 2019 were selected and divided into mild group(42 cases)and severe group(34 cases)according to the disease severity at admission.Another 30 children admitted to the hospital at the same time period for physical examination were included in control group.The changes of levels of serum PCT,CRP and IL-1 were measured in each group at admission and after 15d of treatment.Results The serum levels of PCT,CRP and IL-1 in mild group and severe group were significantly higher than those in control group,and the serum levels of PCT,CRP and IL-1 in severe group were significantly higher than those in mild group(P<0.05).The serum levels of PCT,CRP and IL-1 in the two groups after treatment were significantly lower than those before treatment,and the levels in mild group were significantly lower than those in severe group(P<0.05).Conclusion PCT,CRP and IL-1 are involved in the pathogenesis of bronchial pneumonia in children,and are related to the disease severity,and they can guide clinical diagnosis and evaluation of disease and prognosis.