基于响应面法的静电纺丝制备壳聚糖/聚氧化乙烯的工艺参数优化

Optimization of process parameters for preparation of CS/PEO by electrospinning based on response surface methodology

为了对静电纺丝过程工艺参数进行优化,改善壳聚糖(CS)/聚氧化乙烯(PEO)纳米纤维膜的机械性能,选取CS与PEO质量配比、电压、接收距离作为优化参数,抗拉强度和伸长率作为响应性能指标,按照Box-Benhnken(BBD)设计实验,采用响应曲面分析的方法,建立相对应的预测回归模型并进行方差分析。利用残差概率图进行可靠性验证后,得出了各参数对机械性能影响的显著性及其交互作用对膜的影响。利用Design-Expert软件的Optimization模块优化后得到了各工艺参数间的最优组合:CS与PEO质量配比8︰2、电压15.5 kV、接收距离9.88 cm。

In order to optimize the process parameters of the electrospinning process and improve the mechanical properties of the CS/PEO nanofiber membrane,the mass ratio of CS and PEO,voltage and receiving distance were selected as the optimization parameters,and tensile strength and elongation were used as response performance indicators.According to the Box-Benhnken(BBD)design experiment,the response surface analysis methodology was used to establish the corresponding predictive regression model and conduct analysis of variance.After the reliability verification by the residual probability map,the significance of the influence of each parameter on the mechanical properties and the influence of the interaction on the membrane were obtained.The optimal combination of process parameters was obtained after the optimization with the Optimization module of Design-Expert software:the ratio of CS to PEO 8︰2,the voltage 15.5 kV,and the receiving distance 9.88 cm.