探讨阿司匹林肠溶片联合氯吡格雷治疗急性脑梗死的临床疗效及不良反应

To investigate the clinical efficacy and side effects of aspirin combined with clopidogrel in the treatment of acute cerebral infarction

目的研究阿司匹林肠溶片联合氯吡格雷治疗急性脑梗死的临床疗效及不良反应影响。方法选取本院急性脑梗死患者114例,随机分为研究组(阿司匹林肠溶片联合氯吡格雷)与对照组(阿司匹林肠溶片),各57例,比较两组生活自理能力、神经功能缺损情况、血常规指标与不良反应。结果治疗后,研究组患者的生活自理能力评分显著高于对照组,差异有统计学意义(P<0.05);研究组患者的神经功能缺损评分显著低于对照组,差异有统计学意义(P<0.05)。两组治疗前血常规指标比较差异无统计学意义;治疗后研究组较对照组血常规指标均高,研究组不良反应发生率(5.26%)较对照组(17.54%)低,差异有统计学意义(P<0.05)。结论对急性脑梗死患者采用阿司匹林肠溶片联合氯吡格雷治疗能提高患者的生活质量,改善患者的神经功能,延长血小板聚集时间,改善其血常规指标,显著提高临床疗效,降低不良反应发生率,安全性高,值得借鉴。

Objective To study the clinical efficacy and adverse effects of aspirin combined with clopidogrel in the treatment of acute cerebral infarction. Methods A total of 114 patients with acute cerebral infarction were enrolled in our hospital. They were randomly divided into the study group(by aspirin plus clopidogrel) and the control group(by aspirin), respectively. The blood routine indicators and adverse reactions were compared. Results After treatment, the self-care ability scores of the study group patients were significantly higher than the control group, the difference was significant(P<0.05);the neurological deficits of the study group were significantly lower than the control group, the difference was significant(P<0.05). There was no difference in blood routine parameters between the two groups before treatment. After treatment, the blood group index of the study group was higher than that of the control group. The incidence of adverse reactions in the study group(5.26%) was lower than that of the control group(17.54%), the difference was significant(P<0.05). Conclusion The use of aspirin combined with clopidogrel in patients with acute cerebral infarction can improve the quality of life of patients, improve their neurological function, prolong platelet aggregation time, improve their blood routine indicators, significantly improve clinical efficacy, reduce the incidence of adverse reactions, with high safety, and worth learning.