红树林真菌Aspergillus sp.次级代谢产物及其生物活性（英文）

Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities

从曲霉属海洋真菌(Aspergillus sp.)中分离出17种化合物(1-17),其结构由核磁共振波谱(NMR)、质谱(MS)等谱学方法得以确证。其中,化合物1系首次于自然界中被发现,化合物2-17则为已知化合物。对其中部分化合物进行了初步的生物活性测试。其中,化合物2对RPMI8226,OCI-MY5及MCF-7细胞表现出了中等的抑制活性,化合物10对热应激下的线虫表现出了显著的保护作用。此外,化合物9及16对化脓性链球菌(Streptococcus pyogenes)表现出轻度的抑制作用,而化合物17则对肺炎链球菌(Streptococcus pneumoniae)表现出轻度的抑制作用。

Seventeen compounds(1-17)were isolated from the marine fungus Aspergillus sp.Their structures were determined by nuclear magnetic resonance(NMR)spectroscopy and mass spectrum(MS).Among them,compound 1 was first found as a naturally occurring compound and the known compounds 2-17 were confirmed via spectrum and literatures.The bioactivities of selected compounds were preliminarily evaluated.The compound 2 exhibited moderate inhibitory activities toward three cancer cells,RPMI8226,OCI-MY5,and MCF-7 cells,and compound 10 had significant protective effects on prolonging the survival life of C.elegans under heat stress.In addition,the compound 9 and 7 showed slight inhibition effects against Streptococcus pyogenes and meanwhile the compound 17 possessed slightly inhibitory activity on Streptococcus pneumoniae.