脐带间充质干细胞抗肿瘤作用的研究进展

Antitumor effect of umbilical cord mesenchymal stem cells:research advances

脐带间充质干细胞(UC-MSC)是一种具有高度自我更新能力和多向分化潜能的干细胞群。近年来研究发现,脐带间充质干细胞较其他来源的干细胞在获取、储存和移植等方面具有更突出的优势。脐带间充质干细胞还具有特异性分泌细胞因子,发挥免疫调节作用,或向肿瘤部位递送“药物”等特性。因此,脐带间充质干细胞成为了一种极具研究前景的肿瘤靶向工具。本文就脐带间充质干细胞通过不同途径发挥抗肿瘤作用的机制及其安全性方面研究作一综述。

Umbilical cord mesenchymal stem cells(UC-MSC)are a kind of stem cell group with high self-renewal ability and multi-directional differentiation potential.In recent years,studies have shown that UC-MSC is far more advan⁃tageous than the stem cells from other sources in terms of acquisition,storage and transplantation.UC-MSC also possesses the characteristics of secreting specific cytokines,playing an immunomodulatory role,or delivering“drugs”to the special tumor sites.Therefore,UC-MSC has become a promising tumor-targeting tool.This article reviews recent advances in the research on the antitumor mechanism and safety of UC-MSC.