重组人干扰素α-2b栓联合物理治疗宫颈上皮内瘤变Ⅰ级合并高危HPV阳性疗效观察

Therapeutic effect of recombinant human interferon α-2b suppository combined with physical therapy on Grade Ⅰ cervical intraepithelial neoplasia patients with high-risk HPV positive

目的分析重组人干扰素α-2b栓联合物理治疗合并高危人乳头瘤病毒(HPV)阳性宫颈上皮内瘤变(CIN)Ⅰ级的疗效。方法选取某院CINⅠ级合并高危HPV阳性患者80例(2016年6月~2018年6月),依据随机数字表法分组,每组40例。对照组采用重组人干扰素α-2b栓治疗,研究组在对照组基础上采用物理治疗。比较两组CINⅠ级治疗有效率、治疗后3个月、6个月、9个月HPV转阴率、治疗前后HPV病毒载量、血清炎性因子[白细胞介素-6(IL-6)、白细胞介素-2(IL-2)]水平。结果研究组CINⅠ级治疗有效率89.74%高于对照组71.79%(P<0.05);治疗后3个月、6个月、9个月,研究组HPV转阴率66.67%、82.05%、92.31%高于对照组25.64%、43.59%、53.85%(P<0.05);与对照组比较,治疗后研究组HPV病毒载量较少,血清IL-6、IL-2水平较低(P<0.05)。结论重组人干扰素α-2b栓联合物理治疗CINⅠ级合并高危HPV阳性患者,可提高CINⅠ级治疗有效率,减少HPV病毒载量,减轻炎症反应,提高HPV转阴率。

Objective To analyze the efficacy of recombinant human interferonα-2b suppository combined with physical therapy for GradeⅠcervical intraepithelial neoplasia patients with high-risk HPV positive.Methods Eighty CIN I-grade patients with high-risk HPV positive(June 2016~June 2018)were enrolled in our hospital and grouped according to the random number table method,40 patients in each group.The control group was treated with recombinant human interferonα-2b suppository,and the study group was treated with physical therapy on the basis of the theraphy for the control group.The effective rate of CINⅠ,HPV negative rate at 3 months,6 months,and 9 months after treatment,the HPV viral load before and after treatment,serum inflammatory factors[interleukin-6(IL-6),interleukin-2(IL-2)]level were compared.Results The effective rate of CINⅠin the study group was 89.74%,higher than that in the control group 71.79%(P<0.05);At 3 months,6 months and 9 months after treatment,the HPV conversion rate of the study group was 66.67%,82.05%,92.31%higher than the control group 25.64%,43.59%,53.85%(P<0.05);In comparison,the HPV viral load was lower in the study group and the serumI L-6 and IL-2 levels of the study group were lower(P<0.05).Conclusion Recombinant human interferonα-2b suppository combined with physical therapy for GradeⅠcervical intraepithelial neoplasia patients with high-risk HPV positive can reduce HPV viral load,reduce inflammation and increase HPV conversion rate.