补肾祛瘀汤联合孕三烯酮对子宫内膜异位症伴不孕症患者腹腔镜术后疗效及妊娠率的影响

Effect of Bushen Quyu Decoction combined with gestrinone on the curative effect and pregnancy rate of infertile patients with endometriosis after laparoscopic surgery

目的研究补肾祛瘀汤联合孕三烯酮对子宫内膜异位症伴不孕症患者腹腔镜术后的疗效及妊娠率的影响。方法选取2014年2月至2017年1月在邢台县中心医院诊治的120例子宫内膜异位症伴不孕症患者作为研究对象,将其随机分为对照组和观察组,每组60例患者。观察组患者在对照组患者治疗的基础上联合补肾祛瘀汤,治疗6个月经周期。对照组患者行腹腔镜手术治疗,术后予以孕三烯酮治疗,治疗6个月经周期。检测两组患者血清促卵泡刺激素(FSH)、雌二醇(E2)、促黄体生成素(LH)水平,观察记录症状缓解情况、复发情况、妊娠情况和不良反应发生情况。结果观察组患者治疗总有效率(98.3%)显著高于对照组患者(83.3%),其差异具有统计学意义(P<0.05);观察组患者复发率(1.7%)显著低于对照组患者(15.0%),其差异具有统计学意义(P<0.05)。观察组患者2年妊娠率(68.3%)高于对照组患者(43.3%),其差异具有统计学意义(P<0.05)。治疗后,两组患者FSH、LH和E2水平均有所降低,观察组患者各项指标水平均低于对照组患者,其差异均具有统计学意义(均P<0.05)。对照组患者不良反应发生率(33.3%)高于观察组患者(15.0%),其差异具有统计学意义(P<0.05)。结论对子宫内膜异位症伴不孕症患者实施腹腔镜手术,术后给予补肾祛瘀汤联合孕三烯酮治疗,能够有效调节患者性激素水平,缓解各种症状,降低复发率,提高2年妊娠率,并且不良反应较少。

Objective To study the effect of Bushen Quyu Decoction combined with gestrinone on the efficacy and pregnancy rate of infertile patients with endometriosis after laparoscopic surgery. Methods 120 infertile patients with endometriosis treated in Xingtai Central Hospital from February 2014 to January 2017 were randomly divided into control group and observation group with 60 patients in each group. The patients in the observation group were treated with Bushen Quyu Decoction on the basis of the treatment of the control group for 6-month menstrual cycle. The patients in the control group received laparoscopic surgery and gestrinone after operation for 6-month menstrual cycle. Serum levels of follicle stimulating hormone(FSH), estradiol(E2) and luteinizing hormone(LH) were measured in the two groups. Symptom relief, recurrence, pregnancy and adverse reactions were observed and recorded. Results The total effective rate in the observation group(98.33%) was significantly higher than that in the control group(83.3%), with statistically significant difference(P<0.05). The recurrence rate in the observation group(1.7%) was lower than that in the control group(15.0%), with statistically significant difference(P<0.05). The 2-year pregnancy rate in the observation group(68.3%) was higher than that in the control group(43.3%), with statistically significant difference(P<0.05). After treatment, the levels of FSH, LH and E2 decreased in the two groups, and those in the observation group were lower than those in the control group, with statistically significant differences(all P<0.05). The incidence of adverse reactions in the control group(33.33%) was higher than that of the observation group(15.0%), with statistically significant difference(P<0.05). Conclusions Bushen Quyu Decoction joint with gestrinone can effectively regulate the level of sex hormones, alleviate symptoms, reduce recurrence rate and improve the 2-year pregnancy rate of infertile patients with endometriosis after laparoscopic surgery, with few adverse reactions.