剖腹产对母婴双方的多器官功能、免疫水平及血糖变化的影响

Influence of caesarean section on the multiple organ function, immune level and blood sugar changes of mothers and infants

目的研究剖腹产对母婴双方的多器官功能、免疫水平及血糖变化的影响。方法选取2016年2月至2017年4月湖北省妇幼保健院诊治120例产妇作为研究对象。其中剖宫产产妇和自然分娩产妇各60例,分为自然分娩组和剖宫产组两组。分别对两组产妇以及新生儿的产后肝功能、肾功能、心功能相关血液指标进行比较,同时采用流式细胞术检测静脉血T细胞亚群分布(CD3^+、CD4^+、CD8^+T细胞比例及CD4^+/CD8^+),比较不同组别脐血免疫球蛋白IgG、IgM、IgA水平以及血糖情况。结果两组产妇以及新生儿的肝功能、肾功能以及心功能指标之间的差异无统计学意义(P>0.05);自然分娩产妇的IgG水平显著高于剖宫产组产妇,差异具有统计学意义(P<0.05),其余指标之间的差异无统计学意义(P>0.05);自然分娩产妇的静脉血、母亲指血以及新生儿不同时期血糖均显著高于剖宫产组产妇。结论剖宫产产妇的新生儿免疫功能以及血糖水平均显著低于自然分娩产妇,在临床工作中建议合理把握剖宫产指征,同时对新生儿血糖情况加强监测,避免不良神经系统损伤的发生。

Objective To study the effects of caesarean section on multiple organ function, immune level and blood sugar changes of mothers and infants. Methods 120 maternals treated in Hubei Maternal and Child Health Hospital from February 2016 to April 2017 were selected, including 60 caesarean section maternals and 60 natural delivery maternals. The blood indexes related to postpartum liver function, renal function and new function were compared between the two groups, and the distribution of T lymphocyte subsets(CD3^+, CD4^+) in cord blood was detected by flow cytometry. The ratio of CD4^+, CD8^+T cells and CD4^+/CD8^+, the levels of immunoglobulin IgG, IgM, IgA and blood sugar in cord blood of different groups were compared. Results There was no statistically significant difference in the liver function, renal function and cardiac function between the two groups and neonates(P>0.05). The IgG level of natural delivery maternals was significantly higher than that of cesarean section maternals, with statistically significant difference(P<0.05), and there was no significant difference in other indicators(P>0.05). However, the blood glucose in the umbilical cord blood, maternal finger blood and neonatal blood of natural delivery maternals was significantly higher than that of cesarean section maternals. Conclusions The neonatal immune function and blood sugar levels of cesarean section maternals are significantly lower than those of natural delivery maternals. It is suggested that the indications of cesarean section should be reasonably analyzed in clinical work, and the blood sugar of neonates should be monitored to avoid the occurrence of adverse nervous system injury.