(围)绝经女性HCY、CRP、脂质水平与睡眠质量的相关性分析

Correlation analysis of HCY, CRP, lipid level and sleep quality in perimenopause and postmenopausal women

目的探讨围绝经期及绝经女性血浆同型半胱氨酸(HCY)、C-反应蛋白(CRP)、脂质水平与睡眠质量的相关性。方法选取回顾性分析2017年1月至2019年1月于杭州市妇产科医院(杭州市妇幼保健院)妇科内分泌门诊就诊的217例(围)绝经期患者病历资料进行回顾性分析。对其进行匹兹堡睡眠质量问卷调查,根据PSQI≥8分作为判断睡眠质量的好与差,测定血浆HCY、CRP、脂质水平,比较分析HCY、CRP、脂质水平与睡眠质量的关系。结果睡眠质量差组患者HCY、CRP、甘油三酯(TC)、总胆固醇(TG)、低密度脂蛋白(LDL)水平显著高于睡眠质量好组,差异具有统计学意义(P<0.05),高密度脂蛋白(HDL)水平显著低于睡眠质量好组,差异具有统计学意义(P<0.05)。年龄、文化程度、职业、HCY、CRP、脂质水平(TC、TG、LDL、HDL)等为影响绝经女性睡眠质量的主要因素,差异具有统计学意义(均P<0.05)。校正年龄、文化程度、职业等因素,HCY、脂质水平是影响绝经女性睡眠质量的独立危险因素,差异具有统计学意义(均P<0.05)。结论围绝经期及绝经女性HCY、CRP、脂质水平与睡眠质量显著相关,HCY、脂质水平是影响女性绝经过渡期睡眠质量的独立危险因素,为临床改善睡眠质量提供理论依据。

Objective To investigate the correlation between plasma homocysteine(HCY), C-reactive protein(CRP), lipid levels and sleep quality in perimenopausal and postmenopausal women. Methods A retrospective analysis was performed on the 217 perimenopause/postmenopausal patients who visited the gynecological endocrine outpatient in our hospital from January 2017 to January 2019. Data were collected by Pittsburgh Sleep Quality Index(PSQI), and PSQI≥8 was named as the threshold between poor and good sleep quality. The HCY, CRP, lipid levels were detected and their relationship with sleep quality was compared and analyzed. Results The HCY, CRP, triglyceride(TC), total cholesterol(TG) and low density lipoprotein(LDL) levels of patients with poor sleep quality were higher than those with good sleep quality, while HDL levels were lower than those in good sleep quality group, all with statistically significant differences(P<0.05). Age, education level, occupation, HCY, CRP, lipid level(TC, TG, LDL, HDL) were main influencing factors for sleep quality in perimenopause and postmenopausal women, all with statistically significant differences(all P<0.05). After adjusting for age, education level, occupation and other factors, HCY and lipid levels were independent risk factors for sleep quality in perimenopause and postmenopausal women, all with statistically significant differences(all P<0.05). Conclusions HCY, CRP and lipid levels are significantly correlated with sleep quality in perimenopausal and postmenopausal women, and HCY and lipid levels were independent risk factors for sleep quality, which provides theoretical support for the clinical improvement of sleep quality.