不同给药时机应用肺表面活性物质治疗新生儿呼吸窘迫综合征的临床研究

Clinical Study of Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome at Different Time of Administration

目的:探讨了不同给药时机应用肺表面活性物质治疗新生儿呼吸窘迫综合征的临床效果。方法:选取2017年1月至2018年4月本院收治的呼吸窘迫综合征新生患儿98例,随机分为两组,A组49例,应用肺表面活性物质治疗给药时间控制在<2h,B组49例,应用肺表面活性物质治疗给药时间控制在2~4h之间,将两组临床治疗效果进行对比。结果:A组患儿动脉血气情况明显优于B组,差异具有统计学意义(P<0.05);A组患儿并发症发生率、治愈率和B组患儿无显著差异,无统计学意义(P>0.05)。结论:不同给药时机应用肺表面活性物质治疗新生儿呼吸窘迫综合征的临床效果相对有限。

Objective:To investigate the clinical effect of pulmonary surfactant(PSA)on neonatal respiratory distress syndrome(NRDS)at different time of administration.Methods:98 neonates with respiratory distress syndrome admitted to our hospital from January 2017 to April 2018 were selected and randomly divided into two groups.49 cases in group A were treated with pulmonary surfactant for less than 2 hours,49 cases in group B were treated with pulmonary surfactant for 2 to 4 hours.The clinical effects of the two groups were compared.Results:The arterial blood gas of group A was significantly better than that of group B,with statistical significance(P<0.05).There was no significant difference in the incidence of complications,cure rate and the incidence of complications between group A and group B(P>0.05).Conclusion:The clinical effect of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome at different time of administration is relatively limited.