依达拉奉注射液用于治疗急性脑梗死患者的治疗效果观察

Therapeutic Effect of Edaravone Injection on Patients with Acute Cerebral Infarction

目的:针对急性脑梗死的患者在治疗过程中给予依达拉奉注射液对其治疗效果的影响。方法:56例急性脑梗死患者均分为两组,对照组28例患者接受常规高压氧治疗、阿替普酶溶栓治疗,而研究组28例则同时辅以依达拉奉进行治疗,将血清炎性因子水平、神经功能缺损评分(NIHSS)、椎基底动脉血流最大速度以及血管内皮生长因子(VEGF)水平作为治疗效果的判定指标。结果:与对照组相比,血清炎症因子水平[C反应蛋白、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)]研究组较优(P<0.05);治疗前,椎基底动脉血流最大速度,不具统计学差异(P>0.05)。治疗后研究组基底动脉、左侧椎动脉、右侧椎动脉等指标明显高于对照组(P<0.05);研究组患者VEGF水平和NIHSS评分在治疗7d和14d时水平优于常规组(P<0.05)。结论:在急性脑梗死患者的治疗中辅以依达拉奉可帮助血清因子水平的恢复,同时恢复脑部血液循环,以促进神经功能的恢复,疗效显著。

Objective:To investigate the effect of edaravone injection on the treatment of acute cerebral infarction.Methods:56 patients with acute cerebral infarction were divided into two groups,28 patients in the control group were treated with conventional hyperbaric oxygen therapy and ateplase thrombolysis,while 28 patients in the study group were treated with edara at the same time.Serum levels of inflammatory factors,NIHSS score,maximum velocity of vertebrobasilar artery blood flow and level of vascular endothelial growth factor were used as the criteria for evaluating therapeutic effect.Results:Compared with the control group,the level of serum inflammatory factors(C-reactive protein,IL-8,TNF-α)was better in the study group(P<0.05).Before treatment,the maximum velocity of vertebrobasilar artery blood flow had no statistical difference(P>0.05).After treatment,the indexes of basilar artery,left vertebral artery and right vertebral artery in the study group were significantly higher than those in the control group(P<0.05).The levels of vascular endothelial growth factor and NIHSS score in the study group were better than those in the routine group on the 7th and 14th day after treatment(P<0.05).Conclusion:Edaravone can help the recovery of serum factor level and cerebral blood circulation in patients with acute cerebral infarction,so as to promote the recovery of nerve function.The curative effect is remarkable.