单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效观察

Clinical Efficacy of Monosialoganglioside in Treatment of Neonatal Hypoxic Ischemic Encephalopathy

目的:探讨单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法:选取于本院治疗的104例HIE患儿,随机分为两组,各52例。对照组采取常规对症治疗,在此基础上观察组加用单唾液酸神经节苷脂治疗,对比两组临床疗效、神经行为发育指标及血清炎症因子。结果:对照组治疗总有效率(78.85%)较观察组(94.23%)低,差异有统计学意义(P<0.05);治疗后,两组NSE、NPY、MBP、IL-6、IL-10及TNF-α水平均改善,且观察组较对照组低,差异有统计学意义(P<0.05)。结论:HIE患儿采用单唾液酸神经节苷脂治疗可有效提升临床疗效,改善患儿神经行为功能。

Objective:To investigate the clinical efficacy of monosialoganglioside in treatment of neonatal hypoxic ischemic encephalopathy(HIE).Methods:104 children with HIE who treated in the hospital were selected,and they were randomly divided into two groups,with 52 cases in each group.Control group was given routine symptomatic treatment,while observation group was treated with monosialoganglioside based on control group.The clinical efficacy,neurobehavioral development indexes,serum inflammatory factors were compared between the two groups.Results:The total curative effective rate of control group(78.85%)was lower than that of observation group(94.23%),and the difference was statistically significant(P<0.05);After treatment,the levels of neuron specific enolase(NSE),neuropeptide Y(NPY),myelin basic protein(MBP),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)in the two groups improved,and observation group was lower than control group,and the difference was statistically significant(P<0.05).Conclusion:Monosialoganglioside in treatment of neonatal HIE can effectively increase clinical efficacy,improve neurobehavioral function.