塞来昔布超前镇痛联合椎体成形术治疗老年性骨质疏松性骨折的临床应用研究

Clinical Application of Celecoxib Preemptive Analgesia Combined with PercutaneousVertebroplasty in the Treatment of Elderly Osteoporotic Fractures

目的:研究塞来昔布超前镇痛联合椎体成形术(PVP)治疗老年骨质疏松性骨折(OVCF)的临床应用效果。方法:选取2018年5月至2018年11月我院老年OVCF患者92例,随机均分为两组各46例,均进行PVP手术。术前3d起观察组给予塞来昔布口服,对照组给予布洛芬缓释胶囊口服,比较两组术中及术后镇痛效果。结果:观察组麻醉时间、手术时间以及利多卡因用量低于对照组,差异有统计学意义(P<0.05);两组术前VAS评分无明显差异(P>0.05),观察组穿刺时、灌注骨水泥时及手术结束时VAS评分低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率无统计学差异(P>0.05)。结论:塞来昔布超前镇痛用于老年OVCF患者PVP手术有利于提升术中和术后镇痛效果,为顺利完成手术和患者康复创造有利条件。

Objective:To study the clinical application effects of celecoxib preemptive analgesia combined with percutaneousvertebraplasty(PVP)in the treatment of elderly osteoporotic fractures(OVCF).Methods:92 patients with OVCF in our hospital from May 2018 to November 2018were selected and randomlydivided into two groups,with 46 cases in each group.And they were given PVP surgery,and observation group was given celecoxib orally at 3d before surgery,and control group was given diclofenac orally.The intraoperative and postoperative analgesic effects were compared between the two groups.Results:The anesthesia time,operative time and lidocaine dosage in observation group were lower than those in control group(P<0.05).There was no significant difference in the preoperative VAS score between the two groups(P>0.05),and the VAS scores in observation group were lower than those in control group at puncture,at bone cement perfusion and at the end of surgery(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Preemptive analgesia with celecoxib for PVP surgery in elderly OVCF patients is beneficial to improve the intraoperative and postoperative analgesic effects,and create favorable conditions for successful completion of surgery and rehabilitation of patients.