中药制剂派特灵应用于宫颈高危HPV病毒感染的临床研究

Clinical Study on Traditional Chinese Medicine Preparation Paiteling in the Application of Cervical High-risk HPV Virus Infection

目的:探讨中药制剂派特灵应用于宫颈高危人乳头瘤病毒(HPV)感染的临床疗效。方法:选取宫颈高危HPV病毒感染患者80例作为研究对象,随机分为A组与B组两组,40例/组,A组给予中药制剂派特灵治疗,B组给予注射用胸腺法新治疗,比较两组疗效。结果:A组治疗后TCT检查结果正常率高于B组,炎症率、无明确意义的非典型细胞的改变(ASC-US)率、低度鳞状上皮内病变(lSIL)率低于B组(P<0.05);A组治疗后CD4+T淋巴细胞水平、CD4+/CD8+比值及HPV病毒转阴率高于B组,CD8+T淋巴细胞水平低于B组(P<0.05)。结论:中药制剂派特灵治疗宫颈高危HPV病毒感染临床疗效显著,可显著提高HPV病毒转阴率。

Objective:To explore the clinical efficacy of traditional Chinese medicine(TCM)preparation Paiteling in the application of cervical highrisk human papillomavirus(HPV)infection.Methods:Eighty patients with cervical high-risk HPV virus infection were randomly divided into two groups,group A and group B,40 patients/group according to random number table method.Group A was given traditional Chinese medicine preparation Paiteling,and group B was given injection of thymalfasin.The examination results of cervical Thinprep cytology test(TCT),cervical local immune status,HPV virus negative conversion status and occurrence of adverse reactions were compared between the two groups before and after treatment.Results:The normal rate of TCT test in group A was higher than that in group B.The rate of inflammation,atypical cell change(ASC-US)and low squamous intraepithelial lesion(lSIL)were lower than group B(P<0.05);CD4+T lymphocyte level,CD4+/CD8+ratio and HPV virus negative rate were higher in group A than in group B,and CD8+T lymphocyte level was lower than group B(P<0.05).Conclusions:Traditional Chinese medicine preparation Pateling has significant clinical efficacy in the treatment of cervical high-risk HPV virus infection,and it can significantly improve the negative conversion rate of HPV virus.