阿米卡星肺泡灌洗辅助常规治疗重症肺炎的疗效及预后观察

Curative Effect and Prognosis of Routine Treatment Assisted by Amikacin Alveolar Lavage on Severe Pneumonia

目的:探讨阿米卡星肺泡灌注辅助治疗对重症肺炎的疗效及预后。方法:选取我院收治的80例重症肺炎患者随机分为对照组和观察组,每组40例,两组均给予哌拉西林以及肺泡灌洗进行治疗,观察组肺泡灌洗选取阿米卡星稀释液,对照组选取同等剂量的生理盐水进行灌注,治疗第10天检测并记录呼吸动力学指标、血气指标、血液生化指标、气道炎症因子、治疗有效率以及存活率。结果:治疗后,观察组气道压力及白细胞介素-4、C反应蛋白低于对照组,肺静态顺应性高于对照组(P<0.05);观察组动脉血氧血压与氧合指数高于对照组(P<0.05)。治疗后,观察组治疗有效率及存活率高于对照组(P<0.05)。结论:重症肺炎患者使用阿米卡星肺泡灌洗辅助治疗可以改善患者肺部各项指标并且可以提高患者存活率。

Objective:To investigate the curative effect and prognosis of routine treatment assisted by amikacin alveolar lavage on severe pneumonia.Methods:80 patients with severe pneumonia were randomly divided into the control group and the observation group,40 patients in each group.Both groups were treated with piperacillin and alveolar lavage.The alveolar group was observed.In the lavage,amikacin dilution was selected,and the control group was given the same dose of normal saline for perfusion.The patient was tested and recorded respiratory motility index,blood gas index,blood biochemistry after treatment.Indicators,airway inflammatory factors,treatment effectiveness,and survival rates.Results:After treatment,the airway pressure and interleukin-4 and C-reactive protein in the observation group were lower than those in the control group,and the static compliance of the lung was higher than that in the control group(P<0.05).The arterial oximetry and oxygenation index of the observation group were higher than that of the control group(P<0.05).After treatment,the treatment efficiency and survival rate of the observation group were higher than those of the control group(P<0.05).Conclusions:The adjuvant therapy of amikacin alveolar lavage in patients with severe pneumonia can improve lung indexes,and improve survival rate of patients.