丁苯酞在急性缺血性脑卒中治疗中的应用

Application of Butylphthalide in the Treatment of Acute Ischemic Stroke

目的:观察丁苯酞在急性缺血性脑卒中(AIS)治疗中的应用效果。方法:选取76例急性缺血性脑卒中患者随机分为对照组38例和观察组38例。对照组给予常规治疗,观察组在对照组基础上使用丁苯酞治疗,比较两组治疗的总有效率,神经功能缺损评分,血同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)水平以及不良反应的发生率。结果:观察组治疗后的总有效率较对照组高(P<0.05);观察组治疗后的神经功能缺损评分及Hcy、hs-CRP、IL-8水平均较对照组低(P<0.05);两组治疗后的不良反应发生率差异无统计学意义(P>0.05)。结论:使用丁苯酞治疗AIS的有效率高,可改善神经功能缺损评分及血Hcy、hs-CRP、IL-8水平,不良反应少,临床效果较好。

Objective:To observe the application effect of butylphthalide in the treatment of acute ischemic stroke.Methods:76 patients with acute ischemic stroke were randomly divided into control group and observation group,38 cases in each group.The control group was gvien routine treatment.On this basis,observation group was given butylphthalide.The total response rate of treatment,neurological deficit score,levels of serum homocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP)and interleukin-8(IL-8),and incidence of adverse reactions were compared between the two groups.Results:After treatment,total response rate of observation group was higher than that of control group(P<0.05).After treatment,neurological deficit score,levels of Hcy,hs-CRP and IL-8 in observation group were lower than those in control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusions:The response rate of butylphthalide is high in the treatment of AIS,which can improve score of neurological deficit,and levels of serum Hcy,hs-CRP and IL-8.The adverse reactions are few and the clinical effect is relatively better.