外周血EB病毒DNA与非霍奇金淋巴瘤的预后相关性研究

Study on the relationship between Epstein-Barr virus DNA and prognosis of non-Hodgkin’s lymphoma

目的探讨EB病毒(EBV)在不同类型非霍奇金淋巴瘤中的表达差异,分析外周血EBV-DNA与淋巴瘤临床及预后的相关性。方法采用回顾性研究的方法,收集福建省立医院296例明确诊断为淋巴瘤患者的临床资料,分析不同类型淋巴瘤的临床特点和预后。结果在241例B细胞淋巴瘤和55例T细胞淋巴瘤患者中,T细胞淋巴瘤患者外周血EBV-DNA阳性率高于B细胞淋巴瘤患者,且EBV-DNA阳性的T细胞淋巴瘤和B细胞淋巴瘤患者与其乳酸脱氢酶(LDH)成正相关。预后分析中,T细胞淋巴瘤EBV-DNA阳性患者预后更差,而B细胞淋巴瘤患者预后差异无统计学意义。结论外周血EBV-DNA在不同淋巴瘤类型中的检出率不同,外周血EBV-DNA可能是T细胞淋巴瘤的预后因素。

Objective To investigate the expression of Epstein-Barr virus(EBV)in different types of non-Hodgkin′s lymphoma and to analyze the correlation between EBV-DNA in peripheral blood with the clinical and prognosis of lymphoma.Methods A retrospective study was carried out to collect the clinical data of 296 patients with lymphoma in Fujian Provincial Hospital.The clinical characteristics and prognosis of different types of lymphoma were analyzed.Results In 241 cases of B-cell lymphoma and 55 cases of T-cell lymphoma,the positive rate of EBV-DNA in peripheral blood of T-cell lymphoma patients was higher than that of B-cell lymphoma patients and there was a positive correlation between EBV-DNA T-cell lymphoma patients and B-cell lymphoma patients and lactate dehydrogenase(LDH).In the prognosis analysis,the EBV-DNA positive prognosis of T-cell lymphoma patients was worse than that of B-cell lymphoma patients.Conclusion The detection rate of EBV-DNA in peripheral blood is different in different types of lymphoma.EBV-DNA in peripheral blood may be a prognostic factor for T-cell lymphoma.