昌吉市女性HPV高危感染发生率及与宫颈癌前病变的相关性分析

Incidence of high risk HPV infection and its correlation with cervical precancerous lesions in Changji women

目的研究昌吉市女性人乳头瘤病毒(HPV)高危感染发生率及HPV与宫颈癌前病变的相关性分析,为宫颈癌前病变的预防及治疗提供有效依据。方法选取昌吉市154例于2017年3月-2018年6月本院收治的宫颈癌前病变患者为研究对象(研究组),包括LSIL患者51例,HSIL患者103例,另外选取同期健康女性150例(对照组),观察比较不同组别HPV高危感染发生率、阳性HPV各亚型分布情况、HPV高危感染发生率与宫颈癌前病变的相关性。结果研究组阳性HPV高危感染率(55.84%)明显高于对照组(8.67%),有统计学差异(P<0.05);86例阳性HPV各亚型包括HPV35、HPV18、HPV16、HPV33、HPV52及其他亚型,其中HPV16占比最高(43.02%);LSIL组、HSIL组阳性HPV高危感染率分别为为25.49%、70.87%,两组阳性感染率比较有统计学差异(P<0.05);LSIL组HPV各亚型分布比较无统计学差异(P>0.05);HSIL组各亚型分布比较有统计学差异(P<0.05)。结论HPV高危感染发生率与宫颈癌前病变存在紧密联系,感染率随病程加重而升高,其中HPV16感染率最高,有效预防HPV感染可减少宫颈癌前病变发生率,并提高患者临床疗效。

Objective To investigate the correlation of high-risk HPV infection and cervical precancerous lesions in Changji City.Methods 154 patients with cervical precancerous lesions(the study group)and 150 healthy women(the control group)in our hospital between March 2017 and June 2018 were selected.The study group was further divided into three groups according to the different severity degrees,the LSIL group(n=51),the HSIL group(n=103).The incidence of high-risk HPV infection and the distribution of positive HPV subtypes in different groups were observed and compared.Then the correlation of high-risk HPV infection and cervical precancerous lesions was determined.Results The high-risk infection rate of positive HPV in the study group was significantly higher than that of the control group(55.84%vs 8.67%,P<0.05).The 86 positive HPV subtypes included HPV35,HPV18,HPV16,HPV33,HPV52 and other subtypes,of which HPV 16 accounted for the highest proportion(43.02%).The high-risk infection rates of HPV in the LSIL group and the HSIL group were 25.49%and 70.87%respectively,and there was significant difference between the two groups(P<0.05).There was no significant difference in the distribution of HPV subtypes in the LSIL group(P>0.05).The distribution of HPV subtypes in the HSIL group was significantly different(P<0.05).Conclusion The incidence of high-risk HPV infection is positively correlated with cervical precancerous lesions,among which HPV 16 infection rate is the highest.Effective prevention of HPV infection can reduce the incidence of cervical precancerous lesions and improve the clinical efficacy of patients.