血清降钙素原与C反应蛋白检测用于糖尿病足重度感染患者中的临床价值研究

Clinical Value of Serum Procalcitonin and C-reactive Protein in Patients with Severe Infection of Diabetic Foot

目的研究血清降钙素原(PCT)与C反应蛋白(CRP)检测用于糖尿病足重度感染患者中的临床价值。方法回顾性分析2018年3月-2019年3月该院收治的157例糖尿病足患者临床资料,根据不同感染程度分为3组,轻度感染组41例,中度感染组79例,重度感染组37例,测定三组患者治疗前后的PCT及CRP水平。结果与治疗前相比,治疗后各组PCT及CRP水平均降低,差异有统计学意义(P<0.05);治疗前及治疗后,轻度感染组PCT及CRP水平<中度感染组<重度感染组,差异有统计学意义(P<0.05)。结论 PCT及CRP与炎症反应具有紧密正相关性,可作为糖尿病足患者感染严重程度判断的科学、精准依据。

Objective To investigate the clinical value of serum procalcitonin(PCT) and c-reactive protein(CRP) detection in patients with severe diabetic foot infection. Methods Clinical data of 157 patients with diabetic foot admitted to our hospital from March 2015 to March 2019 were retrospectively analyzed. According to different degrees of infection,they were divided into three groups: mild infection group(41 cases), moderate infection group(79 cases), and severe infection group(37 cases). Results Compared with before treatment, PCT and CRP levels of each group were decreased after treatment, and the difference was statistically significant(P<0.05). Before and after treatment, PCT and CRP levels in the mild infection group were lower than those in the moderate infection group and lower than those in the severe infection group, with statistically significant differences(P<0.05). Conclusion PCT and CRP have a close positive correlation with inflammatory response, which can be used as a scientific and accurate basis for determining the severity of infection in diabetic foot patients.