间充质干细胞治疗银屑病的机制与中医药研究

Study on the mechanism of mesenchymal stem cells in the treatment of psoriasis and traditional Chinese medicine

间充质干细胞(mesenchymal stem cells,MSC)主要来源于中胚层,有自我复制和多种分化的潜能。随着研究的深入,其广泛的免疫调节能力日益受到关注。近年来发现,MSC广泛参与银屑病发生、发展的各个环节,该发现为银屑病的临床治疗提供了新的途径与思路。本文对各组织来源MSC对银屑病炎症发生环节的调节机制进行总结和分析,并归纳总结近年来中医药干预MSC与炎症、细胞增殖方面的研究结果,旨在为通过干预MSC治疗银屑病的临床应用提供新思路。

Mesenchymal stem cells(MSC) are mainly derived from mesoderm,and have self-replication and the potential of multiple differentiation.With the deepening of research,their extensive immunomodulatory ability has been paid more and more attention.In recent years,MSC have been widely involved in the occurrence and development of psoriasis.This pathogenesis provides a new way and thinking for the clinical treatment of psoriasis.In this review,we summarized and analyzed the regulation mechanism of MSC derived from various tissues on the pathogenesis of psoriasis inflammation,and summarized the conclusions of traditional Chinese medicine intervention on MSC and inflammation and cell proliferation in recent years,aiming to provide new ideas for the clinical application of intervention MSC in the treatment of psoriasis.