复方猴头胶囊联合雷贝拉唑治疗胃溃疡的临床研究

Clinical study on Compound Houtou Capsules combined with rabeprazole in treatment of gastric ulcer

目的探讨复方猴头胶囊联合雷贝拉唑钠片治疗胃溃疡的临床疗效。方法选取2018年2月-2019年2月在商洛市中心医院治疗的胃溃疡患者86例,按照治疗方法的差别分为对照组(43例)和治疗组(43例)。对照组口服雷贝拉唑钠肠溶片,20 mg/次,1次/d;治疗组在对照组基础上口服复方猴头胶囊,2 g/次,3次/d。两组患者经4周治疗。观察两组患者临床疗效,同时比较治疗前后两组患者症候积分,血清胃泌素(GAS)、胃动素(MTL)、生长抑素(SS)、血管内皮生长因子(VEGF)、高迁移率族蛋白B1(HMGB-1)、表皮生长因子(EGF)、白细胞介素-1(IL-1)和白细胞介素-17(IL-17)水平,及幽门螺杆菌(Hp)根除率和溃疡愈合率。结果治疗后,对照组和治疗组临床有效率分别为81.40%和97.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者症候评分均显著下降(P<0.05),且治疗组患者这些症候积分明显低于对照组(P<0.05)。治疗后,两组患者血清MTL、GAS、HMGB1、IL-1和IL-17水平显著下降(P<0.05),而SS、VEGF和EGF水平升高(P<0.05),且治疗组患者这些细胞因子水平明显好于对照组(P<0.05)。经治疗,治疗组患者Hp根除率和溃疡愈合率均明显高于对照组(P<0.05)。结论复方猴头胶囊联合雷贝拉唑钠片治疗胃溃疡可有效改善患者临床症状、胃肠激素水平,降低机体炎症反应,促进溃疡愈合。

Objective To explore the clinical efficacy of Compound Houtou Capsules combined with rabeprazole in treatment of gastric ulcer. Methods Patients(86 cases) with gastric ulcer in Shangluo Central Hospital from February 2018 to February 2019 were divided into control(43 cases) and treatment(43 cases) groups based on different treatments. Patients in the control group were po administered with Rabeprazole Sodium Enteric-coated Tablet, 20 mg/time, once daily. Patients in the treatment group were po administered with Compound Houtou Capsules on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, the serum levels of MTL, GAS, HMGB1, IL-1 IL-17, SS, VEGF and EGF, and the eradication rate of Hp and ulcer healing rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67% respectively, and there were differences between two groups(P < 0.05). After treatment, the symptom scores in two groups were significantly decreased(P < 0.05), which in the treatment group were significantly lower than that in the control group(P < 0.05). After treatment, the serum levels of MTL, GAS, HMGB1, IL-1 and IL-17 in two groups were significantly decreased(P < 0.05), the SS, VEGF and EGF levels were significantly increased(P < 0.05), and these cytokine levels in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the eradication rate of Hp and ulcer healing rate in the treatment group were significantly higher than that in the control group(P < 0.05). Conclusion Compound Houtou Capsules combined with rabeprazole in treatment of gastric ulcer can effectively improve the clinical symptoms and the level of gastrointestinal hormones, reduce the inflammatory response, and promote ulcer healing.