骨友灵搽剂联合塞来昔布治疗膝骨关节炎的临床研究

Clinical study on Guyouling Liniment combined with celecoxib in treatment of knee osteoarthritis

目的探讨骨友灵搽剂联合塞来昔布治疗膝骨关节炎的临床疗效。方法选取2017年12月-2018年12月在天津市蓟州区人民医院治疗的膝骨关节炎患者90例,随机分为对照组(45例)和治疗组(45例)。对照组口服塞来昔布胶囊,200 mg/次,1次/d;治疗组在对照组基础上外涂骨友灵搽剂,热敷20 min,2 mL/次,3次/d。两组患者均经过5周的治疗。观察两组患者临床疗效,同时比较治疗前后两组患者疼痛评分、西安大略和麦克马斯特大学骨关节炎指数评分(WOMAC)评分、骨钙素(BGP)、抗酒石酸盐酸性磷酸酶异构体(TRACP-5b)和骨特异性碱性磷酸酶(BALP)水平。结果治疗后,对照组和治疗组临床有效率分别为80.00%和91.11%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者疼痛评分以及疼痛、僵硬和日常活动困难3项WOMAC评分均显著降低(P<0.05),且治疗组患者疼痛评分和WOMAC评分明显低于对照组(P<0.05)。治疗后,两组患者的BGP和BALP水平显著升高(P<0.05),TRACP-5b水平显著降低(P<0.05),且治疗组患者BGP、BALP和TRACP-5b水平明显好于对照组(P<0.05)。结论骨友灵搽剂联合塞来昔布胶囊治疗治疗膝骨关节炎作用显著,具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Guyouling Liniment combined with celecoxib in treatment of knee osteoarthritis. Methods Patients(90 cases) with knee osteoarthritis in the People’s Hospital of Jizhou District, Tianjin from December 2017 to December 2018 were randomly divided into control(45 cases) and treatment(45 cases) groups. Patients in the control group were po administered with Celecoxib Capsules, 200 mg/time, once daily. Patients in the treatment group were po administered with Guyouling Liniment on the basis of the control group, 2 mL/time, hot compress for 20 minutes, three times daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacy was evaluated, and the pain scores, WOMAC scores, and BGP, TRACP-5 b and BALP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 91.11%, respectively, and there were differences between two groups(P < 0.05). After treatment, the pain and WOMAC scores in two groups were significantly decreased(P < 0.05), and these scores in the treatment group were significantly lower than that in the control group(P < 0.05). After treatment, the BGP and BALPlevels in two groups were significantly increased(P < 0.05), but TRACP-5 b level was significantly decreased(P < 0.05), and the bone metabolism indexes in the treatment group were significantly better than those in the control group(P < 0.05). Conclusion Guyouling Liniment combined with celecoxib in treatment of knee osteoarthritis has an obvious curative effect, which has a certain clinical application value.