感染性糖尿病足患者血清白细胞介素表达和感染的关系研究

Relationship between Serum Interleukin Expression and Infection in Patients with Infectious Diabetic Foot

目的研究感染性糖尿病足患者血清白细胞介素表达和感染的关系,为临床提供参考。方法选择2017年6月-2019年3月该院内分科收治的54例感染性糖尿病足患者为研究对象,所有患者均符合糖尿病足的诊断标准。选择31例无糖尿病足的糖尿病患者和50例健康患者分别作为对照组,检查所有入选受试者的IL-6,17水平。结果糖尿病足血清IL-6和IL-17水平高于疾病对照组和健康对照组,差异有统计学意义(P<0.05);疾病对照组血清IL-6和IL-17水平高于对照组,差异有统计学意义(P<0.05);感染患者血清IL-6和IL-17水平分别为:(18.02±1.34)、(87.31±6.45)pg/mL,均显著高于未感染患者,差异有统计学意义(P<0.05);糖尿病足感染患者不同糖尿病足分级之间血清IL-6和IL-17水平差异有统计学意义(P<0.05)。随着糖尿病足分级的增加,血清IL-6和IL-17水平呈显著上升趋势,3组数据之间进行对比差异有统计学意义(P<0.05)。结论在感染性糖尿病足中IL-6和IL-17表达较高,且他们的水平高低与糖尿病足发生率和感染性糖尿病足进展具有十分密切的关系。

Objective To study the relationship between serum interleukin expression and infection in patients with infectious diabetic foot, and provide reference for clinical. Methods A total of 54 patients with infectious diabetic foot admitted to our hospital from June 2017 to March 2019 were enrolled. All patients met the diagnostic criteria for diabetic foot.Thirty-one diabetic patients without diabetes and 50 healthy patients were selected as the control group, and the IL-6,17 levels of all the selected subjects were examined. Results The levels of serum IL-6 and IL-17 in diabetic foot were significantly higher than those in disease control group and healthy control group,the difference was statistically significant(P<0.05). The levels of serum IL-6 and IL-17 in disease control group were higher than those in control group. The difference was significant,the difference was statistically significant(P<0.05);the levels of serum IL-6 and IL-17 in infected patients were(18.02±1.34)pg/mL and(87.31±6.45)pg/mL, respectively, which were significantly higher than those in uninfected patients,,the difference was statistically significant(P<0.05);diabetic foot There were significant differences in serum IL-6 and IL-17 levels between infected diabetic patients with different diabetic foot scores,,the difference was statistically significant(P<0.05). Serum IL-6 and IL-17 levels increased significantly with the increase of the grade of diabetic foot. The difference between the three groups was significant,,the difference was statistically significant(P<0.05).Conclusion The expression of IL-6 and IL-17 is high in infectious diabetic foot, and their level is closely related to the incidence of diabetic foot and the progress of infectious diabetes.