结直肠癌肝转移瘤局部介入治疗应用进展

Progress in local interventional therapy for colorectal cancer with liver metastasis

结直肠癌是世界上死亡率排名前5位的恶性肿瘤,其主要死因是肝转移。结直肠癌发生肝转移多是晚期,其治疗效果较差,生存期较短,严重影响结直肠癌的预后。目前,根治性手术切除是结直肠癌肝转移(Colorectal liver metastasis,CRLM)的一线治疗方法,然而,绝大多数病人在被确诊时已失去手术治疗的机会。国家综合癌症网络(National Comprehensive Cancer Network,NCCN)建议将局部治疗(Locoregional therapy,LRT)用于无法行根治性手术切除且对化疗不敏感或无效的CRLM患者,它主要包括经导管动脉内治疗和消融治疗。本文就局部介入治疗CRLM的应用进展做一综述。

Colorectal cancer is the top 5 malignant tumors in the world,and the main cause of death is liver metastasis.The liver metastasis of colorectal cancer is mostly advanced,its therapeutic effect is poor,and the survival time of patients is short,which seriously affects the prognosis of colorectal cancer patients.Radical surgical resection is currently the first-line treatment for colorectal liver metastasis(CRLM).However,the vast majority of patients have lost the opportunity to undergo surgery when they are diagnosed.The National Comprehensive Cancer Network(NCCN)recommends the use of locoregional therapy(LRT)for CRLM patients who are unable to undergo radical surgery and are insensitive or ineffective for chemotherapy,including transcatheter arterial therapy and ablation therapy.This article reviews the application progress of locoregional therapy for CRLM.