摘要
地屈孕酮是来自天然原料、经过专利工艺生产的与天然黄体酮活性类似的孕激素,在胚胎着床、母-胎界面免疫保护、减少子宫收缩等方面均起到重要调节作用。近年来,随着临床研究的开展及Meta分析总结,发现地屈孕酮在预防或治疗流产及妊娠期高血压、胎儿宫内生长受限等产科并发症方面均有较好的效果。本文就地屈孕酮在维持妊娠、IVF中黄体支持及预防产科并发症方面应用的有效性、安全性及其对子代出生缺陷的影响,结合新的循证医学证据做一综述。
Dydrogesterone is a kind of progestin that is produced by a patented process from natural raw materials and has similar activities to natural progesterone.It plays important regulatory roles in embryo implantation,maternal-fetal immunity and reducing uterine contractions.With the development of clinical studies and collections of Meta-analysis in recent years,it has been found that dydrogesterone has good effects on prevention and management of abortion and obstetric complications,such as pregnancy hypertension,fetal intrauterine growth restrictions.This paper reviews the effectiveness and safety of dydrogesterone on pregnancy maintenance,luteal support in IVF,prevention of obstetric complications and its influence on birth defects of offspring based on new evidence-based medical data.
作者
刘聪
李丽玮
田秦杰
LIU Cong;LI Li-wei;TIAN Qin-jie(Reproductive Medicine Department,Maternal&Child Health Hospital of Qinhuangdao City,Qinhuangdao 066000;Department of Obstetrics&Gynecology,Peking Union Medical College Hospital,Peking Union Medical College/Chinese Academy of Medical Sciences,Beijing 100730)
出处
《生殖医学杂志》
CAS
2020年第1期135-139,共5页
Journal of Reproductive Medicine
关键词
地屈孕酮
先兆流产
复发性流产
早产
出生缺陷
Dydrogesterone
Threatened miscarriage
Recurrent miscarriage
Preterm birth
Birth defects
