利拉鲁肽联合肾炎康复片治疗2型糖尿病肾病的效果观察

Effect of liraglutide combined with nephritis rehabilitation tablets for type 2 diabetic nephropathy

目的探讨利拉鲁肽联合肾炎康复片治疗2型糖尿病肾病的效果。方法选择在本院接受治疗的90例2型糖尿病肾病患者,根据随机数表法将患者分为利拉鲁肽组、肾炎康复片组以及联合用药组,每组各30例。所有患者给予常规治疗,利拉鲁肽组在常规治疗基础上皮下注射利拉鲁肽治疗,肾炎康复片组在常规治疗基础上口服肾炎康复片治疗,联合用药组在常规治疗基础上同时给予利拉鲁肽皮下注射及肾炎康复片口服治疗,3组均连续治疗12周,对比糖代谢指标、肾功能及炎性因子的水平变化情况。结果治疗后,3组空腹血糖(FPG)、饭后2 h血糖(2 hPG)、糖化血红蛋白(HbAlc)水平均降低,且联合用药组低于利拉鲁肽组、肾炎康复片组,利拉鲁肽组低于肾炎康复片组,差异有统计学意义(P<0.05);治疗后,3组血清肌酐、尿素氮水平均下降,且联合用药组低于利拉鲁肽组、肾炎康复片组,肾炎康复片组低于利拉鲁肽组,差异有统计学意义(P<0.05);治疗后,3组血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平均下降,且联合用药组低于利拉鲁肽组、肾炎康复片组,差异有统计学意义(P<0.05)。结论利拉鲁肽联合肾炎康复片可有效降低糖尿病肾病患者血糖水平,减少肾脏的炎症反应,改善肾功能。

Objective To explore the effect of liraglutide combined with Nephritis Rehabilitation Tablets in the treatment of type 2 diabetic nephropathy.Methods Ninety patients with type 2 diabetic nephropathy who had received treatment in the Hospital from January 2018 to March 2019 were enrolled,and then randomly divided into a Liraglutide group,a Nephritis Rehabilitation Tablets group and a combined treatment group,with 30 cases in each group.All patients were given routine treatment.Besides,the Liraglutide group was treated with subcutaneous injection of liraglutide,the Nephritis Rehabilitation Tablets group was treated with oral Nephritis Rehabilitation Tablets,and the combined treatment group was given subcutaneous injection of liraglutide and oral administration of Nephritis Rehabilitation Tablets.The three groups were treated continuously for 12 weeks to compare the changes of glucose metabolism index,renal function and inflammatory factors.ResultsAfter treatment,the levels of FPG,2hPG and HbALc were decreased in the three groups,and the levels in the combined treatment group were lower than the liraglutide group and the Nephritis Rehabilitation Tablets group,and the liraglutide group lower than the Nephritis Rehabilitation Tablets group.The difference was statistically significant(P<0.05).After treatment,the levels of serum creatinine and urea nitrogen decreased in the three groups,and the levels in the combined treatment group were lower than the liraglutide group and the Nephritis Rehabilitation Tablets group,and the Nephritis Rehabilitation Tablets group lower than the liraglutide group.The difference was statistically significant(P<0.05)After treatment,the levels of IL-6,TNF-α,and hs-CRP decreased in the three groups,and the levels in the combined treatment group were lower than the liraglutide group and the Nephritis Rehabilitation Tablets group.The difference was statistically significant(P<0.05).ConclusionFor patients with type 2 diabetic nephropathy,Liraglutide combined with Nephritis Rehabilitation Tablets can help reduce the blood sugar,relieve renal inflammation and improve their renal function.