老年广泛期小细胞肺癌患者的预后分析

Prognostic factors for the survival of extensive stage small cell lung cancer in elderly patients

目的:分析老年广泛期小细胞肺癌患者的独立预后因素。方法:回顾性研究2010年6月至2015年6月在安阳市肿瘤医院治疗的60例老年广泛期小细胞肺癌患者的临床资料,所有患者均经细胞学或组织病理明确诊断。采用Kaplan-Meier法计算生存时间和生存率,采用Log-rank检验单因素分析,对有统计学意义的单因素采用Cox风险模型进行多因素分析。结果:60例老年广泛期小细胞肺癌患者1年、2年、3年生存率分别为38.3%、8.3%、3.3%,中位生存时间为10.0个月。单因素分析显示年龄、ECOG评分、一线化疗疗效、化疗周期数、肝转移情况和合并慢性疾病情况是影响患者预后的因素,P值小于0.05,具有统计学差异。Cox风险模型分析显示,年龄、ECOG评分、一线化疗疗效、化疗周期数和肝转移情况对患者的总生存时间具有显著影响。结论:患者年龄、ECOG评分、一线化疗疗效、化疗周期数和肝转移情况是影响老年广泛期小细胞肺癌的独立预后因素。

Objective:To investigate prognostic factors associated with survival of patients with extensive stage small cell lung cancer(ES-SCLC)in elderly patients.Methods:Clinical data from 60 cases elderly patients with ES-SCLC who were diagnosed through histopathology or cytology between June 2010 and June 2015 in Anyang Tumor Hospital were analyzed.Kaplan-Meier,Log-rank test and Cox proportional hazards regression analysis were preformed to make univariate and multivariate analysis.Results:The 1-year,2-year,3-year overall survival rates of 60 cases elderly patients with ES-SCLC were 38.3%,8.3%and 3.3%,respectively.The median survival time(MST)of patients was 10.0 months.Univariate analysis indicated that age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,hepatic metastasis and chronic disease were significantly influenced survival of elderly patients with ES-SCLC(P<0.05).The multivariate analysis suggested that age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,and hepatic metastasis were independent prognostic factors of survival.Conclusion:The efficacy of age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,and hepatic metastasis are important prognostic factors for elderly patients with ES-SCLC.