硼替佐米皮下注射方案治疗3例POEMS综合征并文献复习

The successful treatment of 3 patients with POEMS syndrome with subcutaneously injected bortezomib based regimen and literature review

目的:探讨含硼替佐米方案治疗POEMS综合征的有效性和安全性。方法:报道3例POEMS综合征经含硼替佐米方案治疗的过程及结果,并对相关文献进行复习。结果:3例病人经化疗后1例神经症状得到明显改善,1例腹胀症状消失,1例神经症状及胸闷、气短症状改善。结论:含硼替佐米方案治疗POEMS综合征患者取得了较好疗效,未出现神经毒副作用。

Objective:To explore the effectiveness and safety of bortezomib based regimen in the treatment of POEMS syndrome.Methods:The process and results of 3 patients with POEMS syndrome treated with bortezomib based regimen were reported,and relevant literatures were reviewed.Results:After chemotherapy,one patient's neurological symptoms were significantly improved,one patient's abdominal distension disappeared,and one patient's neurological symptoms,chest tightness and shortness of breath were improved.Conclusion:The bortezomib regimen was effective in the treatment of POEMS syndrome without neurotoxic side effects.