CD44在输卵管癌组织中的表达及临床意义

The expression and clinical significance of CD44 in fallopian tube carcinoma tissues

目的:检测CD44在原发性输卵管癌组织和正常输卵管组织中的表达情况,分析并探讨其临床表达意义。方法:采用免疫组化SP法检测66例原发性输卵管癌组织和27例正常输卵管组织中CD44的表达情况,分析其与输卵管癌患者临床病理参数及预后的关系。结果:CD44主要定位于细胞膜,亦在细胞质着色,在原发性输卵管癌中CD44的高阳性表达率为68.18%,明显低于正常输卵管组织(88.89%)(P<0.05);CD44的表达与输卵管癌患者各临床病理参数之间并无明显差异性(P>0.05);生存曲线分析显示CD44低阳性表达和FIGO分期晚期的输卵管癌患者总体生存率明显降低(P均<0.05);CD44是影响输卵管癌患者独立预后的风险因素。结论:CD44在原发性输卵管癌组织中表达降低,CD44低表达和FIGO分期均与输卵管癌患者不良预后有关。

Objective:To investigate the expression of CD44 in fallopian tube carcinoma and to further detect the relationship between CD44 and clinicopathological parameters of patients and its prognosis.Methods:Immunohistochemistry method was used to explore the expression of CD44 in 66 cases of fallopian tube carcinoma and 27 cases of normal fallopian tube tissues.The relationship between CD44 and clinicopathological parameters and prognosis of patients with fallopian tube cancer was also analyzed.Results:CD44 was mainly localized in the cell membrane and also stained in cytoplasm.The high positive expression rate of CD44 in primary fallopian tube carcinoma was 68.18%,which was significantly lower than that in normal fallopian tube tissues(88.89%)(P<0.05).There were no significant differences between the clinicopathological parameters in patients with fallopian tube cancer and CD44 expressioon(P>0.05).Survival curve analysis showed that the overall survival rate of patients with low positive expression of CD44 and late FIGO stage was significantly lower(P<0.05).CD44 was the independent risk factor affecting prognosis of patients with fallopian tube cancer.Conclusion:CD44 expression is decreased in primary fallopian tube carcinoma,and low CD44 expression and FIGO stage are associated with poor prognosis in patients with fallopian tube cancer.