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胰腺癌肿瘤微环境的治疗进展与思考 被引量:6

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摘要 胰腺癌预后极差,5年总体生存率仅为7%左右。由于胰腺癌发病隐匿,进展快,早期诊断困难,多数患者失去手术机会,并且胰腺癌对放化疗均不敏感,因此需要探索一种新的有效治疗方式。近年来针对肿瘤微环境代谢特点及相关免疫检查点靶向治疗联合传统药物化疗成为胰腺癌治疗的新思路。本文对胰腺癌微环境的特点、相关免疫及微环境代谢中的治疗进展进行综述,为进一步提高胰腺癌患者的生存率提供新思路。
出处 《中国临床研究》 CAS 2020年第1期110-112,117,共4页 Chinese Journal of Clinical Research
基金 云南省应用基础研究(昆医联合专硕)[2017FE467(-182)]
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  • 1Gregory L. Beatty,Drew A. Torigian,E. Gabriela Chiorean,Babak Saboury,Alex Brothers,Abass Alavi,Andrea B. Troxel,Weijing Sun,Ursina R. Teitelbaum,Robert H. Vonderheide,Peter J. O’Dwyer.A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma[J].Clinical Cancer Research.2013(22)
  • 2Meghna Waghray,Malica Yalamanchili,Marina Pasca di Magliano,Diane M. Simeone.Deciphering the role of stroma in pancreatic cancer[J].Current Opinion in Gastroenterology.2013(5)
  • 3Nagaraj Nagathihalli,Merchant,Jason Castellanos.Emerging targets in pancreatic cancer: epithelial–mesenchymal transition and cancer stem cells[J].OncoTargets and Therapy (default).2013(default)
  • 4Zhongming Tan,Xiaofeng Qian,Runqiu Jiang,Qianghui Liu,Youjing Wang,Chen Chen,Xuehao Wang,Bernhard Ryffel,Beicheng Sun.IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation[J].The Journal of Immunology.2013(4)
  • 5Chad Creighton,Jonathan M. Kurie,Don L. Gibbons.The role of epithelial–mesenchymal transition programming in invasion and metastasis: a clinical perspective[J].Cancer Management and Research (default).2013(default)
  • 6Abasi Ene-Obong,Andrew J. Clear,Jennifer Watt,Jun Wang,Rewas Fatah,John C. Riches,John F. Marshall,Joanne Chin-Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsa,Hemant M. Kocher.Activated Pancreatic Stellate Cells Sequester CD8+ T-Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma[J].Gastroenterology.2013
  • 7Shinichi Yabuuchi,Shweta G. Pai,Nathaniel R. Campbell,Roeland F. de Wilde,Elizabeth De Oliveira,Preethi Korangath,Mirte M. Streppel,Zeshaan A. Rasheed,Manuel Hidalgo,Anirban Maitra,N.V. Rajeshkumar.Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer[J].Cancer Letters.2013(1)
  • 8Lei Zheng,Jing Xue,Elizabeth M. Jaffee,Aida Habtezion.Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma[J].Gastroenterology.2013(6)
  • 9Minoti V. Apte,Jeremy S. Wilson,Aurelia Lugea,Stephen J. Pandol.A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment[J].Gastroenterology.2013(6)
  • 10Geou-Yarh Liou,Heike D?ppler,Brian Necela,Murli Krishna,Howard C. Crawford,Massimo Raimondo,Peter Storz.Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs[J].The Journal of Cell Biology.2013(3)

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