介导巨噬细胞极化的关键转录因子及其与TLRs信号的相关性

Key transcription factors of mediating macrophages polarization and their corr-elation with TLRs signal

巨噬细胞是天然免疫系统中的一个重要成员,可塑性是其最重要的特征,当应对不同的微环境信号时,可被极化为促炎-M1表型和抗炎-M2表型,以发挥不同的功能作用。巨噬细胞的极化过程依赖于许多关键转录因子的调控,在不同疾病中,相关转录因子可直接或间接的作用于目标基因的调控区域,促进促炎或抗炎细胞因子的表达,驱使巨噬细胞功能表型极化。Toll样受体(Toll-like receptors,TLRs)是重要的模式识别受体,不同亚型的TLRs在巨噬细胞表面或胞内表达,调控巨噬细胞极化的关键转录因子与TLRs通路存在交互作用,影响巨噬细胞的极化过程和表型。本文针对介导巨噬细胞极化的关键转录因子及其与TLRs信号的相关性作一综述,以期为TLRs和巨噬细胞的相关研究提供理论参考。

Macrophage is an important member of the innate immune system with an important feature of plasticity.When dealing with different microenvironment signals,macrophages can be polarized into pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype to play different functional roles.The process of macrophage polarization depends on the regulation of many key transcription factors.In different diseases,the related transcription factors can directly or indirectly act on the regulatory region of the target gene and promote the expression of pro-inflammatory or anti-inflammatory cytokines,which drive macrophage functional phenotypic polarization.Toll-like receptors(TLRs) are important pattern recognition receptors and different subtypes of TLRs express on the surface or intracellular of macrophages.The key transcription factors that regulate the polarization of macrophages interact with the TLRs pathway,which affects the polarization process and phenotype of macrophages.In this review,in order to provide theoretical reference for the study of TLRs and macrophages,the key transcription factors mediating macrophage polarization and their correlation with TLRs signal were reviewed.