Smart calcium peroxide with self-sufficience for biomedicine

Oxygen(O2)supplementation plays a key role in the treatment of some hypoxia-associated diseases,such as solid tumors,tissue damage,and type-1 diabetes(T1D).Various strategies have been developed to address the hypoxia aspect of these diseases,such as hyperbaric O2 and liquid or solid O2-generating materials.Calcium peroxide(CaO2)has been regarded as a promising O2 provider in the fields of re・generative medicine(Chang and Wang,2013)and tumor treatment(Huang et al.,2016)because of good biocompatibility,high O2 content(0.2222 g O2 g 1 CaO2),and longtime O2-releasing capacity.Moreover,as the"solid H2O2",CaO2 can react with water(H2O)and quickly generate H2O2,a common reactive O2 species(ROS),which can result in excellent antibacterial activity and antitumor effects.Here we focused on the applications of CaO2 in the field of bio・medicine and summarized the recent progress on this research(Figure 1).