原发性胆汁性胆管炎相关细胞因子的研究进展

Research advances in cytokines associated with primary biliary cholangitis

原发性胆汁性胆管炎(PBC)是一种以肝内中小胆管非化脓性炎症为特征的自身免疫性肝病,发病机制尚不明确,免疫调节在其中起关键作用。细胞因子作为免疫系统的重要成分参与其发病。现将近年来研究发现的与PBC有关的一些促炎细胞因子IL-12、IL-17、IL-9、IL-8、TNFα、IL-6和抗炎细胞因子IL-10及其相关信号通路在PBC中的作用作一综述,以加深对PBC发病机制的认识,进而寻求新的治疗方法。

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by nonsuppurative inflammation of the small- and medium-sized bile ducts in the liver. The pathogenesis of PBC remains unclear, and immunoregulation may play a critical role. As the important components of the immune system, cytokines may be involved in the pathogenesis of PBC. This article reviews related research advances in recent years, including the roles of pro-inflammatory cytokines (interleukin-12, interleukin-17, interleukin-9, interleukin-8, tumor necrosis factor-α, and interleukin-6), the anti-inflammatory cytokine interleukin-10, and their signaling pathways in PBC, so as to deepen the understanding of the pathogenesis of PBC and explore new treatment methods.