玉米肽对慢性酒精中毒小鼠免疫功能的影响

Effect of Corn Peptide on Immune Function of Chronic Alcoholism in Mice

为研究玉米肽对慢性酒精中毒小鼠免疫功能的影响,以昆明小鼠为实验动物,设玉米肽低、中、高剂量组,正常对照组和酒精模型组,连续饲喂5个月,然后测定实验小鼠免疫器官指数和血清细胞因子水平,以及血清和肝脏组织中氧化应激相关指标,并取脾脏和胸腺制作HE病理学组织切片,观察组织病变程度,评价其免疫功能。结果显示,玉米肽可改善慢性酒精中毒小鼠的脾脏和胸腺的损伤状况,其改善效果与剂量呈正相关,玉米肽还可显著提高小鼠血清TNF-α、IL-6、IFN-γ、SOD水平,降低血清及肝脏MDA含量(P<0.05)。长期酒精饲喂可导致小鼠免疫功能降低,玉米肽能够通过调节细胞因子水平以及改善机体氧化应激状态增强机体免疫功能。

To study the effect of corn peptide on immune function of chronic alcoholism in mice,Kunming mice were divided into five groups:Three dosage groups(low,middle and high dose)of corn peptide,normal control group and alcohol model group.After fed for 5 months,the mice were killed to measure the immune organ index,serum cytokine levels,and indicators related to oxidative stress in serum and liver tissues.The spleen and thymus were obtained to observe the pathological changes by HE pathological sections.The results showed that corn peptide could alleviate the damage of spleen and thymus in chronic alcoholism mice with a dose response relationship;corn peptide could significantly increase the levels of TNF-α,IL-6,IFN-γand SOD in serum,decrease the levels of MDA in serum and liver(P<0.05).Long-term alcohol feeding could lead to immune function damage in mice,however,corn peptides could enhance body immunity by regulating cytokine levels and improving oxidative stress state.