卢立康唑乳膏联合柳烯酸溶液喷雾剂治疗马拉色菌毛囊炎疗效观察

Observation of the efficacy of luliconazole cream combined willow acid solution sprays in malassezia folliculitis

目的观察卢立康唑乳膏联合柳烯酸溶液喷雾剂治疗马拉色菌毛囊炎的疗效和安全性。方法102例马拉色菌毛囊炎患者随机分为3组。试验组采用卢立康唑乳膏联合柳烯酸溶液喷雾剂治疗,每日交替外用各1次;对照1组采用卢立康唑乳膏治疗,日1次;对照2组采用柳烯酸溶液喷雾剂治疗,早晚各1次,疗程均4周,观察3组患者疗效及真菌清除率。结果治疗4周后,试验组有效率(88.24%)显著高于对照1组(65.63%),差异有统计学意义(P=0.03),与对照2组(70.96%)相比,差异无统计学意义(P=0.08);试验组、对照1组和对照2组的真菌清除率分别为91.18%、75.00%、80.65%,3组间比较差异无统计学意义(P=0.21)。结论卢立康唑乳膏联合柳烯酸溶液喷雾剂治疗马拉色菌毛囊炎较单用卢立康唑乳膏疗效高,安全性好。

Objective To observe the therapeutic effect and safety of luliconazole cream combined willow acid solution sprays in malassezia folliculitis.Methods 102 patients with malassezia folliculitis were randomly divided into three groups.The patients in the experimental group were treated with luliconazole cream combined willow acid solution sprays,once alternately in turn each morning and evening for 4 weeks;the patients in the first control group were treated with luliconazole cream,once a day for 4 weeks;and the patients in the second control group were treated with willow acid solution sprays,twice a day for 4 weeks.The therapeutic effect and the fungus clearance rate were observed after the treatment for 4 weeks.Results The therapeutic rate of the experimental group was 88.24%,which was higher than that of the first control group,there was a significant difference between the two groups(P=0.03).There was no significant difference between the experimental group and the second control group(P=0.08).The fungus clearance rate in the experimental group(91.18%)was higher than the first control group(75%)and the second control group(80.65%),there was no significant difference among the three groups(P=0.21).Conclusion Luliconazole cream combined willow acid solution sprays is effective and safe in the treatment of malassezia folliculitis.