胆系恶性肿瘤分子治疗的新靶点

New Targets for Molecular Therapy of Biliary Malignant Tumors

胆系恶性肿瘤是一组与胆道相关的上皮性癌,在解剖学上分为肝内(iCCA)、肝门周围(pCCA)和远端(dCCA)亚群。到目前为止,胆系恶性肿瘤仍以手术治疗为主,但很多患者发现时已到晚期,失去了手术机会,而目前仍无有效的化疗方案。因此选择一种有效的靶向药物治疗胆系恶性肿瘤是当务之急,本文讨论了近年来在胆系恶性肿瘤分子研究的一些新的观念,这些分子可能是未来治疗胆系恶性肿瘤的重要靶点。

Biliary tract cancer is a group of epithelial cancers associated with the biliary tract.They are anatomically divided into intrahepatic(iCCA),perihilar(pCCA)and distal(dCCA)subgroups.Up to now,surgical treatment is still the main treatment for malignant biliary tumors,but many patients are in advanced stage when they were diagnosed,the opportunity for surgery was lost,and there is still no effective chemotherapy program.Therefore,it is urgent to find an effective targeted drug.In this paper,we discuss some new ideas and molecular research of malignant biliary tumors in recent years.These molecules may be the promising targets for future treatment of malignant biliary tumors.